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Study Characteristics Study Title: A 1-, 3- & 7-Day Oral (Gavage) Gene Array Toxicity Study in Male SD Rats on Methapyrilene. Acetaminophen: Gene expression profiling of rat livers reveals indicators of potential adverse effects of acetaminophen Acetaminophen: Protein expression profiling of rat serum and livers Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 1 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 10 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 11 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 12 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 13 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 14 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 15 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 16 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 17 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 18 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 2 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 3 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 4 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 5 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 6 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 7 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 8 Affymetrix data from vehicle-treated rats contributed to HESI Base Line Study from Institution 9 Application of 1,2-dichlorobenzene to F344/N rats via oral gavage to evaluate acute toxicity Application of 1,4-dichlorobenzene to F344/N rats via oral gavage to evaluate acute toxicity Application of N-nitrosomorpholine to F344/N rats via oral gavage to evaluate acute toxicity Application of bromobenzene to F344/N rats via oral gavage to evaluate acute toxicity Application of diquat dibromide to F344/N rats via intraperitoneal administration to evaluate acute toxicity Application of galactosamine-HCl to F344/N rats via intraperitoneal administration to evaluate acute toxicity Application of monocrotaline to F344/N rats via oral gavage to evaluate acute toxicity Application of thioacetamide to F344/N rats via oral gavage to evaluate acute toxicity Characterization of gene expression in hematopoetic stem cells and forebrain from recombinant inbred mouse strains Checkpoint responses to ionizing radiation Clofibrate: One, three and seven day oral gene array and toxicity study in the male Sprague Dawley rats performed at Abbott Laboratories Clofibrate: One, three and seven day oral (gavage) gene array and toxicity study of clofibrate in the male Sprague Dawley rat performed at GSK. Evaluation of carcinogenesis with eugenol and methyleugenol via oral gavage in B6C3F1 mice Evaluation of carcinogenesis with oxazepam, o-nitrotoluene, p-nitrotoluene and acetaminophen via feed in male and female B6C3F1 mice Evaluation of clinical signs and RNA expression in male Sprague Dawley rats following exposure to known nephrotoxins: 20-day IP treatment with puromycin Evaluation of variation in the hepatic gene expression in individual male Fischer rats Gene expression library of hepatotoxicants in rat liver deposited by Johnson & Johnson Gene expression profiling of NCI60 panel of cell lines Gene expression profiling of Nrf2-mediated protection against oxidative injury HESI_Cisplatin_SD HESI_Gentamicin Iconix library of hepatotoxicants Methapyrilene: One, three and seven day oral gene array and toxicity study in the male Sprague Dawley rats performed at Abbott Laboratories Molecular mechanism investigation of phenobarbital-induced serum cholesterol elevation in rat livers by microarray analysis Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance TRC Standardization at Center 1 TRC Standardization at Center 2 TRC Standardization at Center 3 TRC Standardization at Center 4 TRC Standardization at Center 5 TRC Standardization at Center 6 TRC Standardization at Center 7 CEBS study accession number: 001-00001-0021-000-5 001-00001-0022-000-6 001-00001-0023-000-7 001-00001-0024-000-8 001-00001-0025-000-9 001-00001-0026-000-0 001-00001-0027-000-1 001-00001-0028-000-2 001-00002-0013-000-7 001-00003-0011-000-6 002-00001-0011-000-5 003-00001-0011-000-6 003-00002-0011-000-7 004-00001-0011-000-7 004-00002-0011-000-8 004-00004-0011-000-0 004-00005-0011-000-1 005-00002-0011-000-9 005-00002-0012-000-0 005-00003-0011-000-9 006-00001-0011-000-9 007-00001-0011-000-0 008-00001-0011-000-1 008-00001-0012-000-2 008-00001-0013-000-3 008-00001-0014-000-4 008-00002-0011-000-2 008-00002-0012-000-3 008-00002-0013-000-4 008-00003-0002-000-3 008-00003-0003-000-4 008-00003-0004-000-5 008-00003-0005-000-6 008-00003-0006-000-7 008-00003-0007-000-8 008-00003-0008-000-9 008-00003-0009-000-0 008-00003-0010-000-2 008-00003-0011-000-3 008-00003-0012-000-4 008-00003-0013-000-5 008-00003-0014-000-6 008-00003-0015-000-7 008-00003-0016-000-8 008-00003-0017-000-9 008-00003-0018-000-0 008-00003-0019-000-1 009-00001-0011-000-2 009-00001-0012-000-3 009-00001-0013-000-4 009-00001-0014-000-5 009-00001-0015-000-6 009-00001-0016-000-7 009-00001-0017-000-8 Study objective / description: Subject type, e.g. Lab animal: Culture Invertebrate Lab animal Stressor Type: Chemical Environmental Genetic Duration unit: day hour hours week Start Date of Study: 01/01/2000 06/17/2000 12/05/2000 01/23/2001 02/14/2001 01/01/2002 01/01/2003 01/31/2003 01/01/2004 03/01/2004 09/08/2004 09/14/2004 09/21/2004 09/22/2004 09/23/2004 10/05/2004 10/13/2004 11/16/2004 11/30/2004 12/07/2004 03/01/2005 07/20/2005 01/01/2006 Expected /observed target organ: Kidney Liver Expected / observed pathology: Necrosis Experimental factors: . Agent Cell Line Compound Compound and Dose Compound and dose Culture,IR Dose Dose&Time Internal Study Nrf2 disruption Sex Strain Sub-group Time Time after irradiation Time&Treatment Tissue,Age,Sex daf-16 allele daf-2 allele Back to Top
Stressor Characteristics Chemical stressor Chemical name: 1,2-Dichlorobenzene 1,4-Dichlorobenzene 1-Naphthylisothiocyanate (ANIT) 2-Acetamidofluorene 3'-hydroxyacetanilide 3-Acetamidophenol (AMAP) 3-Methylcholanthrene 4,4-Methylenedianiline 4-Acetylaminofluorene 4-Methylthiazole Acetaminophen (APAP) Allyl alcohol Amiodarone Amsacrine Aniline Antimycin A3 Aspirin Atorvastatin Bemitradine Benzafibrate Benzbromarone Bromobenzene Buspirone Busulfan Butylated hydroxytoluene (BHT) Cadmium Chloride Captopril Carbon tetrachloride Carmustine Cerium Chloride Chlorambucil Cisplatin Clofibrate Clotrimazole Concanavalin A Coumarin Cyclophosphamide d-Galactosamine Dacarbazine Dichloroacetate Diclofenac Dieldrin Diethylphthalate Diflunisal Diisononylphthlate Dimethylformamide Dimethylmaleate Dimethylnitrosamine Diquat dibromide Disulfiram Doxorubicin Doxylamine Econazole Erythromycin estolate Ethanol Ethynylestradiol Etoposide Eugenol Famotidine Fenbufen Fenofibrate Fluconazole Flufenamic acid Fluoxetine Flurbiprofen Flutamide Fluvastatin Furosemide Gadolinium Galactosamine-HCl Gemfibrozil Gentamicin Glucosamine Glybenclamide Glycine Hexachlorocyclohexane gamma (lindane) Hydrazine hydrate Ibuprofen Indomethacin Isoniazid Isoproterenol Itraconazole Ketoconazole Lipopolysaccharide (LPS) Lovastatin Menadione Metformin Methapyrilene Methotrexate Methyleugenol Metoprolol Miconazole Monocrotaline N,N-Dimethylformamide N-Nitrosodiethylamine N-Nitrosomorpholine Niacin Nimesulide o-Nitrotoluene Oxazepam p-Nitrotoluene Paraquat Perfluorodecanoic acid Perfluoroheptanoic acid Perfluorooctanoic acid Perhexilene Phalloidin Phenacetin Phenobarbital Phenylephrine Phorone Picoline_n_oxide Piperonal Piperonyl butoxide Precocene I Pregnenolone carbonitrile (PCN) Pulegone Puromycin Quercetin Retinol (Vitamin A) Rifampicin Rotenone Simvastatin Sodium arsenite Sodium orthovanadate Streptozocin Sulindac Tacrine Tamoxifen Tannic acid Tetracycline Thioacetamide transAnethole Troglitazone Valproic acid WY-14643 Zymosan A CAS number: 101-77-9 10108-64-2 10217-52-4 10238-21-8 103-90-2 10540-29-1 106-46-7 107-18-6 108-86-1 11028-71-0 1115-70-4 120-57-0 128-37-0 13311-84-7 134523-00-5 13721-39-6 1397-94-0 1405-41-0 1434-54-4 15307-79-6 154-93-8 15663-27-1 15687-27-1 1587-15-1 17598-0206 1772-03-8 18883-66-4 1910-42-5 19774-82-4 2156-56-1 22494-42-4 22916-47-8 23593-75-1 25316-40-9 25812-30-0 27220-47-9 28322-02-3 3/4/4342 305-03-3 315-22-0 33386-08-2 33419-42-0 335-76-2 3521-62-8 3562-84-3 36330-85-5 4180-23-8 41859-67-0 49562-28-9 50-06-6 50-78-2 504-20-1 51-03-6 5104-49-4 51803-78-2 53-86-1 53-96-3 530-78-9 54-31-9 54-85-3 54301-15-4 55-18-5 55-98-1 551-06-4 56-23-5 56-40-6 56-49-5 562-10-7 56392-17-7 57-63-6 58-27-5 58-60-6 58-89-9 58856-93-2 59-05-2 59-67-6 59-89-2 59333-67-4 5984-95-2 60-54-8 60-57-1 604-75-1 6055-19-2 61-76-7 62-44-2 62-53-3 62-55-5 62-75-9 621-42-1 62571-86-2 637-07-0 6385-62-2 64-17-5 65277-42-1 66-94-2 6724-53-4 68-12-2 68515-48-0 693-95-8 7440-54-2 75330-75-5 76824-35-6 7784-46-5 7790-86-5 79902-63-9 83-79-4 84-66-2 84625-61-6 86386-73-4 88-72-2 88133-11-3 91-64-5 91-80-5 93-15-2 93957-54-1 95-50-1 97-53-0 97-77-8 99-66-1 99-99-0 Missing natural product Environmental stressor Stressor name: 1.5Gy IR Pure oxygen Room air UNC sham Genetic stressor Target locus Chromosome 2 (hyperoxia susceptibility locus 1; Hsl1) DAF-16 DAF-2 Recombinant Mouse Strain
Show Advanced Search Hide Advanced Search Study Characteristics | Chemical Stressor Characteristics | Genetic Stressor Characteristics | Chemical Stressor Protocol | Environment Stressor Protocol | Genetic Stressor Protocol | Animal Husbandry | Cell Culture Conditions | Euthanasia | Harvest Study Characteristics Study sub-discipline type ChooseAcute toxicology Carcinogenesis Genetics Toxicology Study design type ChooseParallel Pharmacological action name No data available Publication title Publication author Back to Top Chemical Stressor Characteristics Chemical Class Of Agent ChooseAlcohol dehydrogenase inhibitor NSAID Toxicant Toxicant, free oxygen radical generator Biological Class Of Agent ChooseAlcohol dehydrogenase inhibitor NSAID PPAR alpha agonist, fibrate ester Toxicant Toxicant, free oxygen radical generator Metabolites No data available Formula Choose(C15H25NO3)2.C4H6O6 (C2H5)2NCSS2CSN(C2H5)2 (CH3)2C=CHCOCH=C(CH3)2 (CH3)2NNO 151.16 2-(CF3C6H4NH)C6H4CO2H 2-(CH3CO2)C6H4CO2H 3,4-(HO)2C6H3CH(OH)CH2NHCH(CH3)2.HCl AsNaO2 C10H7NCS C11H11F3N2O3 C11H8O2 C12H11ClN2O5S C12H14Cl2N2.xH2O C12H14O2 C12H15ClO3 C12H18N6O3 C12H8Cl6O C13H12F2N6O C13H12N2O5S C13H18O2 C13H8F2O3 C14H10Cl2NNaO2 C14H19Cl2NO2 C15H13NO C15H22O3 C17H12Br2O3 C17H18F3NO.HCl C18H14Cl4N2O C18H15Cl3N2O C19H16ClNO4 C19H20ClNO4 C19H30O5 C19H35N.C4H4O4 C20H21ClO4 C20H22N8O5 C20H24O2 C21H19N3O3S.HCl C21H31N5O2.HCl C22H17ClN2 C22H24N2O8.xH2O C22H31NO2 C23H22O6 C23H28ClN3O5S C24H26FNO4 C24H36O5 C25H29I2NO3.HCl C25H38O5 C26H28Cl2N4O4 C27H29NO11.HCl C29H32O13 C2H6O C33H35FN2O5 C35H38Cl2N8O4 C3H7NO C40H71NO14.C12H26SO4 C4H10N2O C4H5NS C5H9Cl2N3O2 C6H10N6O C6H10O5 C6H13NO5.HCl C6H4-1,2-(CO2C2H5)2 C6H4-1,2-(CO2C9H19)2 C6H5C6H3(F)CH(CH3)CO2H C6H5C6H4CO(CH2)2CO2H C6H5NH2 C6H5NO2 C6H6Cl6 C7H15Cl2N2O2P.H2O C8-H9-NO2 C8H15N3O7 C8H15N7O2S3 C8H16O2 C8H6O3 C8H9NO2 C9H15NO3S C9H6O2 CF3(CF2)8CO2H CH2(C6H4NH2)2 CH3CH=CHC6H4OCH3 CH3CONHC6H4OC2H5 CH3SO2O(CH2)4OSO2CH3 CdCl2 CeCl3 Cl2CHCO2Na HCON(CH3)2 HOC6H4CH(CH2NHCH3)OH.HCl NH2C(=NH)NHC(=NH)N(CH3)2.HCl NH2CH2COOH NH2NH2,xH2O, Na3VO4 Pt(NH3)2Cl2 Molecular Weight Choose102.1358 1056.39 123.11 129.91017 138.21 144.2114 146.14 148.2 150.13 151.1626 152.94 157.25 162.14 165.62 172.18 179.22 180.16 182.18 183.32 183.91 185.24 190.24 198.26 203.67 206.28 214.05 215.63 217.29 222.24 223.27 242.7017 244.26 246.3 246.48 247.72 250.2 250.337 254.28 257.16 265.22 268.35 276.21 279.1 281.23 290.83 294.31 296.4 296.54 300.05 304.22 306.2742 308.31 318.13 32.05 330.74 337.45 338.44 341.49 344.8368 345.79 357.79 360.8313 361.8194 380.91 381.6835 393.56 394.42 404.5396 411.4721 416.1286 418.5662 418.61 421.96 424.08 429.92 444.43 454.44 46.0688 494 514.08 531.4309 558.6398 579.98 588.56 681.77 684.81 705.6334 73.09 73.0944 74.08 75.07 93.13 99.15 Back to Top Genetic Stressor Characteristics Target Gene Type ChooseNuclear factor Transcription factor Mutation Description ChooseLoss of function Mice with targeted disruption of Nrf2 had suppressed expression of several ARE(antioxidant response element)-bearing antioxidant/detoxifying enzyme genes and their enzymatic activities after hyperoxia exposure, and these mice were significantly more susceptible to pulmonary oxygen toxicity, relative to wild-type mice. NULL Wild type allele Copy Number No data available Genetic Stressor Type No data available Back to Top Chemical Stressor Protocol Vehicle Choose0.1% Tween 80 0.2% (w/w) hydroxypropyl methylcellulose (HPMC) in sterile water 0.2% hydroxymethylcellulose 0.2% hydroxypropyl methylcellulose (HPMC) 0.4% (w/v) aqueous methylcellulose 0.5 % Natrosol 250 HX 0.5 percent aqueous methylcellulose 0.5% Methocel 0.5% methylcellulose 0.5% methylcellulose plus 0.1% polysorbate 80 in distilled water 0.5% methylcellulose/0.2% polysorbate 80 0.8% Hydroxypropylmethylcellulose (HPMC) in DI water. 0.9% Saline 0.9% saline 1% aqueous carboxymethylcellulose (CMC) solution 1% methylcellulose 1.0% (V/V) polysorbat 80 (Tween 80) + 1.0% sodium carboxymethyl-cellulose (Blanose® CMC 7MF PH) 10% acacia + 0.1% antifoam 2% HPMC (hydroxypropyl methylcellulose) / 1% Tween 80, adjusted to pH 2 with methanesulfonic acid 2% HPMC/1% Tween in Water Carboxymethyl cellulose Corn oil Cremophor-EL Deionized water/PEG 400 (1:1) Distilled water Ethanol Hydroxymethylpropyl cellulose. Hydroxypropylmethyl cellulose with PS80 Isotonic saline Methocel Methylcellulose Millipore water None Olive oil Ora PlusT, pH 7.0 Ora-PlusT, adjusted to pH 2 with methanesulfonic acid PEG-400 Phosphate buffered saline Saline Sterile saline Sterile water TED_Carboxymethylcellulose Unspecified Untreated Water Water containing 0.5%w/v methylcellulose acetone in feed then evaporated corn oil Frequency Choose1 Daily Once Subjects were dosed daily at 9-10 a.m. Monday to Friday for 2 weeks. The chemical was in the feed for 2 weeks. daily Route ChooseGavage IM IP In feed Interperitoneal Intraperitoneal Intraperitonieal Intravenous None Oral Oral gavage PO Subcutaneous interperitoneal Dose Range Unit Not enabled Percent Purity Not enabled Mixture Description Not enabled Concentration Used To Dose Unit Not enabled Volume Used To Dose Choose0.0 mL/kg 1.0 mL/kg 10.0 mL/kg 2.0 mL/kg 2.3-2.8 ml 3.0 mL/kg 5.0 mL/kg Back to Top Environmental Stressor Protocol Exposure Unit ChooseGy L/minute Sham Treatment ChooseRoom air UNC sham Frequency Unit No data available Site Or Route Of Administration No data available Back to Top Genetic Stressor Protocol Change Type (KO, RNAi, etc.) No data available Nature Of Expression Change (constituitive, etc. Not enabled Inducer ChooseUnknown Promoter Name No data available Genus Promoter Not enabled Species Promoter Not enabled Promoter Responds To... Not enabled Location Of Target Gene No data available Strain Information - original name Not enabled Backcross Information Unit Genotype ChooseDAF-16 glp-4 daf-16 glp-4 daf-2(e1370) glp-4 daf-2(m577) glp-4 Back to Top Animal Husbandry Diet Name Choose3893 5002 Certified Rodent Chow (Tekland 7012C, Madison, WI) Certified rodent chow #5002C / Purina Mills Inc. Harlan Teklad Rodent Diet Irradiated NTP 2000 wafer feed Irradiated NTP-2000 wafer LabDiet Certified Rodent Diet 5002 NTP 2000 diet NTP2000 Nafag 9433 PMI Feeds, Inc., certified Rodent Chow #5002, pellets Provimi Kliba 3883.0.15 Purified AIN-76A diet Purina Rodent Chow Purina Rodent Chow No. 5002 R&M No1, SQC, pelleted diet, supplied by special Diets Services LTD , England Rat and Mouse No. 1 expanded; batch 7025 Diet Source ChooseGardners, PA Yokohama, Japan Diet Availability ChooseDaily at 9-10 a.m. Monday to Friday ab libitum ad libitum ad libitum during the 12-hour light period of daily light cycle ad libitum except as noted ad libitum, except overnight (approximately 16 hours) prior to terminal necropsy. restricted Withdrawn Prior To Disposition? Not enabled None Hours Of Light Unit Choose per 24 hrs Animals Per Cage Cage Area Unit Not enabled Back to Top Cell Culture Conditions Medium Name ChooseDMEM Peptone NGM RPMI-1640 with phenol red, 2 mM glutamine and 5% fetal calf serum S media Medium Source ChooseInvitrogen Serum Supplements Not enabled Growth Factor Not enabled Antibiotics Used ChooseNone none Culture Surface Treatment Not enabled Splitting Frequency Unit Chooseper week Arrest Method ChooseConfluence arrest Arrest Point No Data Available Pre Treatment Type Not enabled Pre Treatment Method Not enabled Back to Top Euthanasia Method Type ChooseAnesthetic overexposure Blood was collected from the abdominal vein at necropsy Cervical dislocation Exsanguination Exsanguination via abdominal aorta under isoflurane IP injection of Nembutal then exsanguination Inhalation of carbon dioxide from a regulated source Inhalation of isoflurane followed by cervical dislocation Sacrificed with CO2 from a regulated source Vena cava and aorta were severed under CO2 analgesia Anesthetic Used ChooseEther Halothane Isoflurane Ketamine:xylazine:acepromazine Nembutal Pentobarbital Other Treatment At Necropsy Not enabled Steps Taken To Reduce Stress Not enabled Order Of Sacrifice Not enabled Back to Top Harvest Method Type Harvest Not enabled Agents Used Not enabled Temperature Of Procedure Unit Not enabled Time Required For Harvest Unit Not enabled Back to Top
