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Study Information
Study Attribute Value
CEBS Accession Number: 002-01013-0001-0000-8
Chemical Name: 1,1,1,2-Tetrachloroethane
CASRN: 630-20-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 592953_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/19/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 462 0.442 9.24 25.5 0.000
Test Chemical 1,1,1,2-Tetrachloroethane 
15.8       
 50 1044 515 0.493 10.30 25.5 11.579 
52.7       
 50 1046 502 0.480 10.04 25.5 8.554 
158         
 50 1044 554 0.531 11.08 25.5 20.028 
527         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 521 828 1.589 33.12 25.5 259.474
Trend: 2.597        
Probability: 0.005        

Trial #: 2    Activation: No Activation    Date: 08/04/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 491 0.468 9.82 26.0 0.000
Test Chemical 1,1,1,2-Tetrachloroethane 
200         
 50 1045 545 0.522 10.90 26.0 11.529 
248         
 50 1051 623 0.593 12.46 35.0 26.763 
300         
 0 0 0 0.000 0.00 35.0 N/A 
348         
 0 0 0 0.000 0.00 35.0 N/A 
400         
 25 513 297 0.579 11.88 35.0 23.807
Positive Control Mitomycin-C 
 0.005     
 25 520 749 1.440 29.96 26.0 208.025
Trend: 3.343        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/19/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 496 0.472 9.92 25.5 0.000
Test Chemical 1,1,1,2-Tetrachloroethane 
158         
 50 1049 485 0.462 9.70 25.5 -2.125 
527         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 523 840 1.606 33.60 25.5 240.005
Trend: -0.336        
Probability: 0.632        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/04/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 468 0.452 9.36 26.0 0.000
Test Chemical 1,1,1,2-Tetrachloroethane 
248         
 50 1045 499 0.478 9.98 26.0 5.604 
300         
 50 1028 511 0.497 10.22 26.0 9.932 
348         
 50 1025 506 0.494 10.12 26.0 9.174 
400         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 527 895 1.698 35.80 26.0 275.584
Trend: 1.509        
Probability: 0.066