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Study Information
Study Attribute Value
CEBS Accession Number: 002-01013-0009-0000-6
Chemical Name: 1,1,1,2-Tetrachloroethane
CASRN: 630-20-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 499400_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/20/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0002
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.25 ± 1.67 0.0000
Test Chemical 1,1,1,2-Tetrachloroethane 
300         
 8 3.50 ± 0.91 0.4224
  
600         
 8 3.00 ± 1.36 0.5805
  
1200         
 8 8.25 ± 1.67 0.0012
Vehicle Control No Stressor 
 0         
 8 3.25 ± 1.06 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/18/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9406
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 19.50 ± 3.76 0.0000
Test Chemical 1,1,1,2-Tetrachloroethane 
900         
 8 4.50 ± 1.45 0.6302
  
1200         
 8 2.50 ± 0.63 0.9686
Vehicle Control No Stressor 
 0         
 8 5.00 ± 1.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/28/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 11.50 ± 1.68 0.0000
Test Chemical 1,1,1,2-Tetrachloroethane 
300         
 8 1.25 ± 0.65 0.5000
  
600         
 8 2.00 ± 0.93 0.2008
  
1200         
 8 8.75 ± 2.33 0.0000
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed