Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01015-0020-0000-1 |
Chemical Name: | 1,1,1-Trichloroethane |
CASRN: | 71-55-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 247192 |
Study Result: | Negative |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 74 | 100 | 179 | 80 | 74 |
70 | 82 | 185 | 88 | ||||
73 | 98 | 141 | 64 | ||||
76 | 120 | 143 | 63 | ||||
Test Chemical | 1,1,1-Trichloroethane | 0.26 | 62 | 66 | 90 | 48 | 51 |
56 | 54 | 91 | 54 | ||||
0.33 | 94# | 72 | 81 | 29 | 30 | ||
92 | 75 | 83 | 30 | ||||
0.41 | 89# | 95 | 54 | 20 | |||
0.51 | 65 | 18 | 77 | 40 | 33 | ||
91# | 16 | 70.5 | 26 | ||||
0.64 | |||||||
Positive Control | Ethyl Methane Sulfonate | 500 | 29 | 26 | 657 | 751 | 751* |
29# | 24 | 772.5 | 883 | ||||
47 | 44 | 865 | 618 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 87 | 115 | 67 | 26 | 28 |
83 | 85 | 76 | 30 | ||||
Test Chemical | 1,1,1-Trichloroethane | 0.21 | 67 | 56 | 102 | 51 | 41 |
48 | 42 | 44 | 30 | ||||
0.26 | 47 | 48 | 35 | 25 | 29 | ||
82 | 70 | 82 | 33 | ||||
0.33 | 83 | 75 | 71 | 29 | 35 | ||
46 | 41 | 57 | 41 | ||||
0.41 | 68 | 53 | 77 | 38 | 28 | ||
67 | 53 | 36 | 18 | ||||
0.51 | 83 | 44 | 76 | 30 | |||
126r | 71 | 130 | 34 | ||||
0.64 | |||||||
91# | 45 | 80 | 29 | ||||
0.8 | |||||||
Positive Control | Ethyl Methane Sulfonate | 500 | 50 | 40 | 995 | 668 | 542* |
49 | 30 | 975 | 663 | ||||
60 | 49 | 534 | 296 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 62 | 102 | 49 | 26 | 28 |
62 | 98 | 64 | 34 | ||||
56 | 92 | 60 | 36 | ||||
64 | 108 | 33 | 17 | ||||
Test Chemical | 1,1,1-Trichloroethane | 0.21 | 56 | 56 | 42 | 25 | 24 |
59 | 58 | 43 | 24 | ||||
74 | 111 | 52 | 23 | ||||
0.26 | 62 | 76 | 40 | 22 | 22 | ||
63 | 82 | 52 | 28 | ||||
67 | 89 | 35 | 17 | ||||
0.33 | 61 | 60 | 72 | 39 | 27 | ||
68 | 79 | 41 | 20 | ||||
62 | 72 | 39 | 21 | ||||
0.41 | 57 | 52 | 49 | 29 | 35 | ||
62 | 44 | 62 | 33 | ||||
59 | 47 | 75 | 42 | ||||
0.51 | 68 | 41 | 59 | 29 | 23 | ||
76 | 49 | 47 | 21 | ||||
39 | 19 | 22 | 19 | ||||
0.64 | |||||||
Positive Control | Ethyl Methane Sulfonate | 500 | 41 | 46 | 720 | 585 | 558* |
37 | 47 | 659 | 588 | ||||
43 | 48 | 649 | 501 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 63 | 102 | 227 | 120 | 119 |
63 | 95 | 218 | 116 | ||||
65 | 108 | 208 | 106 | ||||
58# | 95 | 232.5 | 134 | ||||
Test Chemical | 1,1,1-Trichloroethane | 0.21 | 72 | 73 | 207 | 97 | 88 |
67 | 86 | 160 | 80 | ||||
0.26 | 86 | 90 | 221 | 85 | 93 | ||
66 | 71 | 199 | 101 | ||||
0.33 | 66 | 62 | 197 | 100 | 95 | ||
78 | 64 | 211 | 91 | ||||
0.41 | 63 | 43 | 214 | 113 | 107 | ||
62 | 45 | 189 | 101 | ||||
0.51 | 41 | 8 | 160 | 130 | 123 | ||
46 | 12 | 158 | 116 | ||||
0.64 | |||||||
Positive Control | 3-Methylcholanthrene | 5 | 34 | 32 | 470 | 465 | 452* |
44# | 28 | 451.5 | 345 | ||||
32 | 30 | 516 | 546 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 79 | 96 | 109 | 46 | 57 |
91 | 110 | 154 | 57 | ||||
73 | 94 | 146 | 67 | ||||
Test Chemical | 1,1,1-Trichloroethane | 0.21 | 61 | 72 | 68 | 37 | 38 |
91 | 89 | 105 | 38 | ||||
0.26 | 77 | 68 | 127 | 55 | 37 | ||
94 | 83 | 54 | 19 | ||||
0.33 | 124r | 104 | 183 | 49 | |||
113 | 93 | 185 | 54 | ||||
0.41 | 71 | 54 | 74 | 35 | 41 | ||
62 | 54 | 86 | 46 | ||||
0.51 | 68 | 56 | 153 | 75 | 71 | ||
80 | 49 | 159 | 67 | ||||
0.64 | 77 | 23 | 210 | 91 | 106* | ||
65 | 15 | 236 | 120 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 35 | 19 | 395 | 382 | 349* |
36 | 21 | 362 | 340 | ||||
34 | 20 | 327 | 325 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 75 | 96 | 83 | 37 | 41 |
88 | 103 | 116 | 44 | ||||
72 | 93 | 73 | 34 | ||||
93 | 108 | 135 | 48 | ||||
Test Chemical | 1,1,1-Trichloroethane | 0.21 | 60 | 59 | 75 | 42 | 37 |
65 | 66 | 55 | 28 | ||||
77 | 79 | 99 | 43 | ||||
0.26 | 70 | 67 | 93 | 44 | 37 | ||
66 | 57 | 52 | 26 | ||||
66 | 61 | 81 | 41 | ||||
0.33 | 61 | 51 | 42 | 23 | 35 | ||
66 | 52 | 83 | 42 | ||||
74 | 63 | 89 | 40 | ||||
0.41 | 77 | 53 | 83 | 36 | 35 | ||
68 | 50 | 43 | 21 | ||||
56 | 35 | 79 | 47 | ||||
0.51 | 58 | 21 | 62 | 35 | 45 | ||
62 | 31 | 101 | 55 | ||||
67 | 27 | 92 | 46 | ||||
0.64 | |||||||
Positive Control | 3-Methylcholanthrene | 5 | 43 | 35 | 405 | 316 | 291* |
43 | 33 | 356 | 279 | ||||
50 | 39 | 413 | 276 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination