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Study Information
Study Attribute Value
CEBS Accession Number: 002-01017-0001-0000-2
Chemical Name: 1,1,2,2-Tetrachloroethane
CASRN: 79-34-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 838914_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/07/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 546 0.528 10.92 25.8 0.000
Test Chemical 1,1,2,2-Tetrachloroethane 
16.8       
 50 1035 655 0.633 13.10 25.8 19.963 
55.8       
 50 1042 895 0.859 17.90 25.8 62.818 
168         
 50 1030 995 0.966 19.90 31.0 83.119
Positive Control Mitomycin-C 
 0.005     
 25 516 807 1.564 32.28 25.8 196.464
Trend: 12.852        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/07/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 556 0.534 11.12 25.8 0.000
Test Chemical 1,1,2,2-Tetrachloroethane 
168         
 50 1046 578 0.553 11.56 25.8 3.460
Positive Control Cyclophosphamide 
1.5       
 25 517 955 1.847 38.20 25.8 245.851
Trend: 0.000        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/14/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 505 0.486 10.10 25.5 0.000
Test Chemical 1,1,2,2-Tetrachloroethane 
451         
 50 1037 617 0.595 12.34 25.5 22.532 
502         
 50 1031 645 0.626 12.90 25.5 28.838 
558         
 50 1017 650 0.639 13.00 25.5 31.624
Positive Control Cyclophosphamide 
1.5       
 25 518 773 1.492 30.92 25.5 207.321
Trend: 4.618        
Probability: 0.000