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Study Information
Study Attribute Value
CEBS Accession Number: 002-01017-0002-0000-3
Chemical Name: 1,1,2,2-Tetrachloroethane
CASRN: 79-34-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 838914_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2   

Trial #:1   Activation: No Activation    Date: 05/11/1982    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,1,2,2-Tetrachloroethane 
453         
 79 3 0.038 4.0 1 0.013 1.0 0 0.000 0.0 2 0.025 2.0 
503         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0 
553         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
603         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
653         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
704         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
804         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 50 47 0.940 44.0 13 0.260 22.0 24 0.480 30.0 10 0.200 2.0
Trend: 1.776 0.805 2.344  
Probability: 0.038 0.210 0.010  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/28/1982    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0 2 0.020 2.0
Test Chemical: 1,1,2,2-Tetrachloroethane 
503         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
553         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
603         
 100 2 0.020 1.0 2 0.020 1.0 0 0.000 0.0 0 0.000 0.0 
653         
 41 1 0.024 2.0 0 0.000 0.0 0 0.000 0.0 1 0.024 2.0
Positive Control: Cyclophosphamide 
10         
 50 34 0.680 46.0 18 0.360 26.0 15 0.300 26.0 1 0.020 1.0
Trend: -0.948 0.292 -0.919  
Probability: 0.829 0.385 0.821  


Trial #:2   Activation: No Activation    Date: 04/28/1982    Harvest Time: 20.5 hour(s)   Trial Call:   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 0.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,1,2,2-Tetrachloroethane 
452         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 14 0.280 26.0 7 0.140 14.0 5 0.100 10.0 2 0.040 4.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000