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Study Information
Study Attribute Value
CEBS Accession Number: 002-01019-0001-0000-4
Chemical Name: 1,1,2-Trichloroethane
CASRN: 79-00-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 834917_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 10/08/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 420 0.400 8.40 25.7 0.000
Test Chemical 1,1,2-Trichloroethane 
166.7       
 50 1050 490 0.467 9.80 25.7 16.556 
500         
 50 1049 504 0.480 10.08 25.7 20.000 
1700         
 50 1047 688 0.657 13.76 32.0 64.122 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 619 0.591 12.38 25.7 47.522
Mitomycin-C 
 0.01      
 5 104 214 2.058 42.80 25.7 413.933
Trend: 8.089        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/29/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 524 179 0.342 7.16 25.8 0.000
Test Chemical 1,1,2-Trichloroethane 
1000         
 25 522 282 0.540 11.28 32.8 58.146 
1710         
 25 520 296 0.569 11.84 32.8 66.635 
2510         
 25 518 336 0.649 13.44 32.8 89.884 
3750         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 525 318 0.606 12.72 25.8 77.315
Mitomycin-C 
 0.01      
 5 104 218 2.096 43.60 25.8 513.623
Trend: 6.658        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/08/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 431 0.410 8.62 25.7 0.000
Test Chemical 1,1,2-Trichloroethane 
500         
 50 1049 443 0.422 8.86 25.7 2.882 
1700         
 50 1051 492 0.468 9.84 25.7 14.045 
5000         
 50 1046 595 0.569 11.90 25.7 38.579
Positive Control Cyclophosphamide 
 0.4       
 50 1047 675 0.645 13.50 25.7 57.061
Cyclophosphamide 
2         
 5 104 162 1.558 32.40 25.7 279.484
Trend: 5.478        
Probability: 0.000