Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01019-0001-0000-4 |
Chemical Name: | 1,1,2-Trichloroethane |
CASRN: | 79-00-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 834917_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 420 | 0.400 | 8.40 | 25.7 | 0.000 |
Test Chemical | 1,1,2-Trichloroethane | 166.7 | 50 | 1050 | 490 | 0.467 | 9.80 | 25.7 | 16.556 |
500 | 50 | 1049 | 504 | 0.480 | 10.08 | 25.7 | 20.000 | ||
1700 | 50 | 1047 | 688 | 0.657 | 13.76 | 32.0 | 64.122 | ||
5000 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1048 | 619 | 0.591 | 12.38 | 25.7 | 47.522 |
Mitomycin-C | 0.01 | 5 | 104 | 214 | 2.058 | 42.80 | 25.7 | 413.933 | |
Trend: | 8.089 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 25 | 524 | 179 | 0.342 | 7.16 | 25.8 | 0.000 |
Test Chemical | 1,1,2-Trichloroethane | 1000 | 25 | 522 | 282 | 0.540 | 11.28 | 32.8 | 58.146 |
1710 | 25 | 520 | 296 | 0.569 | 11.84 | 32.8 | 66.635 | ||
2510 | 25 | 518 | 336 | 0.649 | 13.44 | 32.8 | 89.884 | ||
3750 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 25 | 525 | 318 | 0.606 | 12.72 | 25.8 | 77.315 |
Mitomycin-C | 0.01 | 5 | 104 | 218 | 2.096 | 43.60 | 25.8 | 513.623 | |
Trend: | 6.658 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 431 | 0.410 | 8.62 | 25.7 | 0.000 |
Test Chemical | 1,1,2-Trichloroethane | 500 | 50 | 1049 | 443 | 0.422 | 8.86 | 25.7 | 2.882 |
1700 | 50 | 1051 | 492 | 0.468 | 9.84 | 25.7 | 14.045 | ||
5000 | 50 | 1046 | 595 | 0.569 | 11.90 | 25.7 | 38.579 | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1047 | 675 | 0.645 | 13.50 | 25.7 | 57.061 |
Cyclophosphamide | 2 | 5 | 104 | 162 | 1.558 | 32.40 | 25.7 | 279.484 | |
Trend: | 5.478 | ||||||||
Probability: | 0.000 |