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Study Information
Study Attribute Value
CEBS Accession Number: 002-01019-0002-0000-5
Chemical Name: 1,1,2-Trichloroethane
CASRN: 79-00-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 834917_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/09/1986    Harvest Time: 20.2 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 2 0.010 1.0 2 0.010 1.0 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 1,1,2-Trichloroethane 
377         
 200 9 0.045 4.0 6 0.030 3.0 2 0.010 0.5 1 0.005 0.5 
2513         
 200 8 0.040 4.0 1 0.005 0.5 5 0.025 2.5 2 0.010 1.0 
3750         
 200 11 0.055 4.5 3 0.015 1.5 7 0.035 3.0 1 0.005 0.5 
5000         
 86 24 0.279 22.1 3 0.035 3.5 21 0.244 19.8 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 60 0.300 23.5 28 0.140 13.5 32 0.160 14.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 24 0.960 68.0 12 0.480 44.0 12 0.480 44.0 0 0.000 0.0
Trend: 3.922 -0.041 5.005  
Probability: 0.000 0.516 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/09/1986    Harvest Time: 10 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 3.0 1 0.005 0.5 3 0.015 1.5 2 0.010 1.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 3 0.015 1.5 0 0.000 0.0 1 0.005 0.5
Test Chemical: 1,1,2-Trichloroethane 
377         
 200 18 0.090 7.5 3 0.015 1.5 13 0.065 5.0 2 0.010 1.0 
2500         
 200 12 0.060 5.5 2 0.010 1.0 5 0.025 2.0 5 0.025 2.5 
3750         
 200 17 0.085 8.5 7 0.035 3.5 8 0.040 4.0 2 0.010 1.0 
5000         
 98 27 0.276 25.5 2 0.020 2.0 24 0.245 23.5 1 0.010 1.0
Positive Control: Cyclophosphamide 
7.5       
 200 29 0.145 13.0 3 0.015 1.5 24 0.120 10.5 2 0.010 1.0
Cyclophosphamide 
37.5       
 25 16 0.640 52.0 5 0.200 20.0 10 0.400 36.0 1 0.040 4.0
Trend: 4.314 0.907 4.466  
Probability: 0.000 0.182 0.000  


Trial #:2   Activation: No Activation    Date: 01/20/1987    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,1,2-Trichloroethane 
3784         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0 
4400         
 50 10 0.200 14.0 0 0.000 0.0 10 0.200 14.0 0 0.000 0.0 
5000         
 70 18 0.257 21.4 3 0.043 4.3 15 0.214 18.6 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 25 0.250 22.0 13 0.130 11.0 12 0.120 11.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 21 0.840 56.0 12 0.480 44.0 9 0.360 28.0 0 0.000 0.0
Trend: 4.408 1.409 4.377  
Probability: 0.000 0.079 0.000