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Study Information
Study Attribute Value
CEBS Accession Number: 002-01022-0001-0000-8
Chemical Name: 1,1-Dichloroethane
CASRN: 75-34-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 508873_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/10/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 384 0.366 7.68 25.8 0.000
Test Chemical 1,1-Dichloroethane 
500.6       
 50 1050 475 0.452 9.50 25.8 23.580 
1700         
 50 1049 470 0.448 9.40 25.8 22.396 
5000         
 50 1050 486 0.463 9.72 25.8 26.442
Positive Control Mitomycin-C 
 0.001     
 50 1049 744 0.709 14.88 25.8 93.750
Mitomycin-C 
 0.01      
 5 104 180 1.731 36.00 25.8 372.806
Trend: 3.152        
Probability: 0.001        

Trial #: 2    Activation: No Activation    Date: 09/18/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 181 0.345 7.24 25.5 0.000
Test Chemical 1,1-Dichloroethane 
3000         
 25 525 183 0.349 7.32 25.5 1.105 
4000         
 25 525 180 0.343 7.20 25.5 -0.552 
5000         
 25 524 243 0.464 9.72 25.5 34.510
Positive Control Mitomycin-C 
 0.001     
 25 525 332 0.632 13.28 25.5 83.425
Mitomycin-C 
 0.01      
 5 105 230 2.190 46.00 25.5 535.359
Trend: 2.829        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/10/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 351 0.334 7.02 25.8 0.000
Test Chemical 1,1-Dichloroethane 
500.6       
 50 1050 425 0.405 8.50 25.8 21.198 
1700         
 50 1047 506 0.483 10.12 25.8 44.710 
5000         
 50 1050 520 0.495 10.40 25.8 48.289
Positive Control Cyclophosphamide 
 0.4       
 50 1049 763 0.727 15.26 25.8 117.793
Cyclophosphamide 
2         
 5 105 184 1.752 36.80 25.8 424.716
Trend: 6.253        
Probability: 0.000