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Study Information
Study Attribute Value
CEBS Accession Number: 002-01022-0002-0000-9
Chemical Name: 1,1-Dichloroethane
CASRN: 75-34-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 508873_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/01/1986    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 2 0.010 1.0 1 0.005 0.5
Test Chemical: 1,1-Dichloroethane 
2500         
 200 4 0.020 2.0 1 0.005 0.5 2 0.010 1.0 1 0.005 0.5 
3800         
 200 8 0.040 3.5 1 0.005 0.5 5 0.025 2.0 2 0.010 1.0 
5000         
 200 5 0.025 2.0 3 0.015 1.0 1 0.005 0.5 1 0.005 0.5
Positive Control: Mitomycin-C 
 0.25      
 200 19 0.095 9.0 7 0.035 3.0 11 0.055 5.5 1 0.005 0.5
Mitomycin-C 
 0.75      
 25 13 0.520 48.0 5 0.200 20.0 7 0.280 24.0 1 0.040 4.0
Trend: 0.399 0.568 -0.040  
Probability: 0.345 0.285 0.516  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/01/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 1 0.005 0.5
Test Chemical: 1,1-Dichloroethane 
2500         
 200 15 0.075 3.0 3 0.015 1.5 1 0.005 0.5 11 0.055 1.0 
3800         
 200 7 0.035 3.5 4 0.020 2.0 2 0.010 1.0 1 0.005 0.5 
5000         
 200 8 0.040 3.5 3 0.015 1.5 4 0.020 1.5 1 0.005 0.5
Positive Control: Cyclophosphamide 
7.5       
 200 25 0.125 11.0 6 0.030 3.0 18 0.090 8.0 1 0.005 0.5
Cyclophosphamide 
37.5       
 25 28 1.120 60.0 13 0.520 44.0 14 0.560 36.0 1 0.040 4.0
Trend: 1.570 0.997 1.178  
Probability: 0.058 0.159 0.119