| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01022-0002-0000-9 |
| Chemical Name: | 1,1-Dichloroethane |
| CASRN: | 75-34-3 |
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
| NTP Study ID: | 508873_CA |
| Study Result: | Negative |
| Activation | Trial | Trial Call |
|---|---|---|
| No Activation | 1 | Negative |
| Induced Rat Liver S9 | 1_S9 | Negative |
| Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
| Vehicle Control: | Negative (Not Specified) | 0 | 200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 |
| Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | |
| Test Chemical: | 1,1-Dichloroethane | 2500 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 |
3800 | 200 | 8 | 0.040 | 3.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.0 | 2 | 0.010 | 1.0 | ||
5000 | 200 | 5 | 0.025 | 2.0 | 3 | 0.015 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | ||
| Positive Control: | Mitomycin-C | 0.25 | 200 | 19 | 0.095 | 9.0 | 7 | 0.035 | 3.0 | 11 | 0.055 | 5.5 | 1 | 0.005 | 0.5 |
| Mitomycin-C | 0.75 | 25 | 13 | 0.520 | 48.0 | 5 | 0.200 | 20.0 | 7 | 0.280 | 24.0 | 1 | 0.040 | 4.0 | |
| Trend: | 0.399 | 0.568 | -0.040 | ||||||||||||
| Probability: | 0.345 | 0.285 | 0.516 | ||||||||||||
| Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
| Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
| Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | |
| Test Chemical: | 1,1-Dichloroethane | 2500 | 200 | 15 | 0.075 | 3.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 11 | 0.055 | 1.0 |
3800 | 200 | 7 | 0.035 | 3.5 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | ||
5000 | 200 | 8 | 0.040 | 3.5 | 3 | 0.015 | 1.5 | 4 | 0.020 | 1.5 | 1 | 0.005 | 0.5 | ||
| Positive Control: | Cyclophosphamide | 7.5 | 200 | 25 | 0.125 | 11.0 | 6 | 0.030 | 3.0 | 18 | 0.090 | 8.0 | 1 | 0.005 | 0.5 |
| Cyclophosphamide | 37.5 | 25 | 28 | 1.120 | 60.0 | 13 | 0.520 | 44.0 | 14 | 0.560 | 36.0 | 1 | 0.040 | 4.0 | |
| Trend: | 1.570 | 0.997 | 1.178 | ||||||||||||
| Probability: | 0.058 | 0.159 | 0.119 | ||||||||||||