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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01022-0002-0000-9 |
Chemical Name: | 1,1-Dichloroethane |
CASRN: | 75-34-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 508873_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Negative (Not Specified) | 0 |
200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 |
200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | |
Test Chemical: | 1,1-Dichloroethane | 2500 |
200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 |
3800 |
200 | 8 | 0.040 | 3.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.0 | 2 | 0.010 | 1.0 | ||
5000 |
200 | 5 | 0.025 | 2.0 | 3 | 0.015 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | ||
Positive Control: | Mitomycin-C | 0.25 |
200 | 19 | 0.095 | 9.0 | 7 | 0.035 | 3.0 | 11 | 0.055 | 5.5 | 1 | 0.005 | 0.5 |
Mitomycin-C | 0.75 |
25 | 13 | 0.520 | 48.0 | 5 | 0.200 | 20.0 | 7 | 0.280 | 24.0 | 1 | 0.040 | 4.0 | |
Trend: | 0.399 | 0.568 | -0.040 | ||||||||||||
Probability: | 0.345 | 0.285 | 0.516 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Dimethyl Sulfoxide | 0 |
200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 |
200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | |
Test Chemical: | 1,1-Dichloroethane | 2500 |
200 | 15 | 0.075 | 3.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 11 | 0.055 | 1.0 |
3800 |
200 | 7 | 0.035 | 3.5 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | ||
5000 |
200 | 8 | 0.040 | 3.5 | 3 | 0.015 | 1.5 | 4 | 0.020 | 1.5 | 1 | 0.005 | 0.5 | ||
Positive Control: | Cyclophosphamide | 7.5 |
200 | 25 | 0.125 | 11.0 | 6 | 0.030 | 3.0 | 18 | 0.090 | 8.0 | 1 | 0.005 | 0.5 |
Cyclophosphamide | 37.5 |
25 | 28 | 1.120 | 60.0 | 13 | 0.520 | 44.0 | 14 | 0.560 | 36.0 | 1 | 0.040 | 4.0 | |
Trend: | 1.570 | 0.997 | 1.178 | ||||||||||||
Probability: | 0.058 | 0.159 | 0.119 |