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Study Information
Study Attribute Value
CEBS Accession Number: 002-01028-0001-0000-4
Chemical Name: 1,2,3,4-Diepoxybutane DL
CASRN: 298-18-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 449785
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 71 103 68 32 29
    68 118 68 33
    77 95 41 18
    58 83 55 31
Test Chemical 1,2,3,4-Diepoxybutane DL 
 0.3125    
 55 81 80 49 50*
    64# 114 97 51
  
 0.625     
 63 69 139 74 89*
    58# 61 181.5 104
  
1.25      
 34# 33 195 189 200*
    31 26 195 211
  
2.5       
 7r 3 70 318
    7r 2 76 390
  
5         
   
Positive Control Ethyl Methane Sulfonate 
250         
 70# 73 312 149 148*
    80# 103 352.5 147

Nonactivation Trial: 3 Experiment Call:
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 59 95 112 63 64
    72 92 152 70
    63 103 93 49
    71 110 154 72
Test Chemical 1,2,3,4-Diepoxybutane DL 
 0.4388    
 56 60 512 308 307*
    52 57 481 306
  
 0.8775    
 28 16 730 885 1087*
    18 8 690 1290
  
1.755     
 3r 1 195 1950
    4r 1 245 2130
  
3.51      
   
Positive Control Ethyl Methane Sulfonate 
250         
 43 61 408 319 282*
    55 65 402 245

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination