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Study Information
Study Attribute Value
CEBS Accession Number: 002-01029-0001-0000-5
Chemical Name: 1,2,3,4-Tetrachlorobenzene
CASRN: 634-66-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 053141_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/02/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1047 415 0.396 8.30 26.5 0.000
Test Chemical 1,2,3,4-Tetrachlorobenzene 
1.51      
 50 1044 386 0.370 7.72 26.5 -6.721 
5         
 50 1046 416 0.398 8.32 26.5 0.337 
15.1       
 50 1034 434 0.420 8.68 26.5 5.893 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1055 510 0.483 10.20 26.5 21.960
Mitomycin-C 
 0.01      
 10 210 227 1.081 22.70 26.5 172.713
Trend: 1.112        
Probability: 0.133        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/02/1985    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1037 470 0.453 9.40 26.0 0.000
Test Chemical 1,2,3,4-Tetrachlorobenzene 
15.1       
 50 1045 456 0.436 9.12 26.0 -3.721 
50         
 50 1045 509 0.487 10.18 26.0 7.469 
151         
 50 1032 553 0.536 11.06 30.0 18.230
Positive Control Cyclophosphamide 
 0.5       
 50 1042 675 0.648 13.50 26.0 42.928
Cyclophosphamide 
2.5       
 10 211 254 1.204 25.40 26.0 165.603
Trend: 3.102        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/24/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1031 412 0.400 8.24 26.0 0.000
Test Chemical 1,2,3,4-Tetrachlorobenzene 
75.5       
 50 1029 518 0.503 10.36 26.0 25.973 
101         
 50 1041 514 0.494 10.28 26.0 23.559 
126         
 50 1022 576 0.564 11.52 26.0 41.037 
151         
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1031 604 0.586 12.08 26.0 46.602
Cyclophosphamide 
2.5       
 10 205 229 1.117 22.90 26.0 179.539
Trend: 4.835        
Probability: 0.000