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Study Information
Study Attribute Value
CEBS Accession Number: 002-01029-0002-0000-6
Chemical Name: 1,2,3,4-Tetrachlorobenzene
CASRN: 634-66-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 053141_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/24/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Acetone 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 1,2,3,4-Tetrachlorobenzene 
10.1       
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
30.1       
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
101         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
151         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 54 0.270 20.5 16 0.080 6.5 38 0.190 15.5 0 0.000 0.0
Mitomycin-C 
5         
 50 29 0.580 42.0 11 0.220 22.0 18 0.360 28.0 0 0.000 0.0
Trend: -0.356 1.401 -0.777  
Probability: 0.639 0.081 0.781  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/24/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Acetone 
0         
 200 17 0.085 3.5 2 0.010 1.0 5 0.025 2.5 10 0.050 1.0
Test Chemical: 1,2,3,4-Tetrachlorobenzene 
15.1       
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0 
50         
 200 12 0.060 4.5 0 0.000 0.0 11 0.055 4.5 1 0.005 1.0 
151         
 200 8 0.040 3.5 0 0.000 0.0 8 0.040 3.5 0 0.000 0.0 
301         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 10 30 3.000 80.0 3 0.300 30.0 7 0.700 60.0 20 2.000 2.0
Trend: 0.076 -1.816 0.791  
Probability: 0.470 0.965 0.214