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Study Information
Study Attribute Value
CEBS Accession Number: 002-01032-0001-0000-9
Chemical Name: 1,2,3,4-Tetrahydro-9-acridinamine monohydrochloride
CASRN: 1684-40-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: A14474_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/23/1992    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 5 0.025 1.0 2 0.010 1.0 3 0.015 1.0 0 0.000 0.0
Test Chemical: 1,2,3,4-Tetrahydro-9-acridinamine monohydrochloride 
7         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
15         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
32         
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0 
70         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 9 0.360 32.0 5 0.200 20.0 4 0.160 16.0 0 0.000 0.0
Trend: 1.267 0.728 -0.451  
Probability: 0.103 0.233 0.674  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/23/1992    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2,3,4-Tetrahydro-9-acridinamine monohydrochloride 
23         
 200 6 0.030 3.0 5 0.025 2.5 1 0.005 0.5 0 0.000 0.0 
50         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 0.5 0 0.000 0.0 
108         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
230         
 230 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 10 0.400 32.0 8 0.320 32.0 2 0.080 4.0 0 0.000 0.0
Trend: -1.607 -1.290 -0.952  
Probability: 0.946 0.901 0.830