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Study Information
Study Attribute Value
CEBS Accession Number: 002-01033-0001-0000-0
Chemical Name: 1,2,3,5-Tetrachlorobenzene
CASRN: 634-90-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 338317_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1044 399 0.382 7.98 26.5 0.000
Test Chemical 1,2,3,5-Tetrachlorobenzene 
1.26      
 50 1044 384 0.368 7.68 26.5 -3.759 
5         
 50 1046 444 0.424 8.88 26.5 11.065 
12.6       
 50 1047 410 0.392 8.20 26.5 2.462 
50         
 50 1047 450 0.430 9.00 30.5 12.459 
126         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1048 486 0.464 9.72 26.5 21.340
Mitomycin-C 
 0.01      
 10 209 196 0.938 19.60 26.5 145.379
Trend: 2.021        
Probability: 0.022        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1048 379 0.362 7.58 26.0 0.000
Test Chemical 1,2,3,5-Tetrachlorobenzene 
5         
 50 1046 341 0.326 6.82 26.0 -9.854 
12.6       
 50 1044 374 0.358 7.48 26.0 -0.941 
50         
 0 0 0 0.000 0.00 0.0 N/A 
126         
 50 1041 361 0.347 7.22 26.0 -4.109
Positive Control Cyclophosphamide 
 0.5       
 50 1042 557 0.535 11.14 26.0 47.812
Cyclophosphamide 
2.5       
 10 209 231 1.105 23.10 26.0 205.624
Trend: -0.168        
Probability: 0.567