Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01033-0002-0000-1 |
Chemical Name: | 1,2,3,5-Tetrachlorobenzene |
CASRN: | 634-90-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 338317_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Acetone | 0 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 1,2,3,5-Tetrachlorobenzene | 5 | 200 | 16 | 0.080 | 3.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 10 | 0.050 | 1.0 |
12.6 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
50 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
75.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 200 | 41 | 0.205 | 17.5 | 14 | 0.070 | 7.0 | 27 | 0.135 | 12.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 5 | 20 | 15 | 0.750 | 60.0 | 7 | 0.350 | 30.0 | 8 | 0.400 | 40.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.795 | -0.583 | -0.490 | ||||||||||||
Probability: | 0.787 | 0.720 | 0.688 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Acetone | 0 | 200 | 6 | 0.030 | 2.0 | 1 | 0.005 | 0.5 | 5 | 0.025 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 1,2,3,5-Tetrachlorobenzene | 7.55 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
25.1 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
75.5 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
126 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 35 | 16 | 0.457 | 28.6 | 6 | 0.171 | 17.1 | 9 | 0.257 | 17.1 | 1 | 0.029 | 1.0 |
Trend: | -0.822 | -0.944 | -0.287 | ||||||||||||
Probability: | 0.795 | 0.827 | 0.613 |