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Study Information
Study Attribute Value
CEBS Accession Number: 002-01036-0001-0000-3
Chemical Name: 1,2,3-Benzotriazole
CASRN: 95-14-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 770824_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/10/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 475 0.467 9.50 26.0 0.000
Test Chemical 1,2,3-Benzotriazole 
50         
 50 1018 466 0.458 9.32 26.0 -1.991 
167         
 50 1033 676 0.654 13.52 33.5 40.111 
500         
 50 1021 674 0.660 13.48 33.5 41.339 
1670         
 0 0 0 0.000 0.00 33.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1019 644 0.632 12.88 26.0 35.313
Mitomycin-C 
 0.01      
 5 102 202 1.980 40.40 26.0 324.012
Trend: 7.450        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/14/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 487 0.472 9.74 26.0 0.000
Test Chemical 1,2,3-Benzotriazole 
502         
 50 1014 532 0.525 10.64 34.0 11.072 
1005         
 50 1019 647 0.635 12.94 34.0 34.419 
1500         
 50 1012 643 0.635 12.86 34.0 34.512 
2000         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1017 561 0.552 11.22 26.0 16.781
Mitomycin-C 
 0.01      
 5 104 179 1.721 35.80 26.0 264.376
Trend: 5.848        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/10/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 451 0.442 9.02 26.0 0.000
Test Chemical 1,2,3-Benzotriazole 
167         
 50 1021 493 0.483 9.86 26.0 9.206 
500         
 50 1033 524 0.507 10.48 26.0 14.724 
1670         
 50 1004 510 0.508 10.20 26.0 14.884 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1018 693 0.681 13.86 26.0 53.960
Cyclophosphamide 
2         
 5 101 209 2.069 41.80 26.0 368.003
Trend: 2.259        
Probability: 0.012        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/02/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1019 460 0.451 9.20 26.0 0.000
Test Chemical 1,2,3-Benzotriazole 
2000         
 50 1018 431 0.423 8.62 26.0 -6.212 
2500         
 50 1026 489 0.477 9.78 26.0 5.579 
3000         
 50 1018 504 0.495 10.08 32.0 9.673 
3500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1018 726 0.713 14.52 26.0 57.981
Cyclophosphamide 
2         
 5 103 212 2.058 42.40 26.0 355.948
Trend: 1.976        
Probability: 0.024