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Study Information
Study Attribute Value
CEBS Accession Number: 002-01038-0001-0000-5
Chemical Name: 1,2,3-Trichloropropane
CASRN: 96-18-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 539595_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/05/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 416 0.398 8.32 25.8 0.000
Test Chemical 1,2,3-Trichloropropane 
14.2       
 50 1048 401 0.383 8.02 25.8 -3.974 
47.2       
 50 1046 423 0.404 8.46 25.8 1.488 
141.7       
 50 1047 420 0.401 8.40 25.8 0.672 
472         
 0 0 0 0.000 0.00 25.8 N/A
Positive Control Mitomycin-C 
5         
 50 1050 1270 1.210 25.40 25.8 203.544
Trend: 0.347        
Probability: 0.364        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/05/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 411 0.397 8.22 25.8 0.000
Test Chemical 1,2,3-Trichloropropane 
1.417     
 50 1033 401 0.388 8.02 25.8 -2.150 
4.724     
 45 921 397 0.431 8.82 25.8 8.655 
14.17      
 50 1027 530 0.516 10.60 25.8 30.084 
47.24      
 0 0 0 0.000 0.00 0.0 N/A 
142         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1021 1027 1.006 20.54 25.8 153.549
Trend: 4.363        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/13/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 469 0.450 9.38 25.5 0.000
Test Chemical 1,2,3-Trichloropropane 
39.68      
 50 1030 738 0.717 14.76 25.5 59.342 
49.6       
 50 1033 877 0.849 17.54 25.5 88.804 
59.51      
 50 1028 864 0.840 17.28 25.5 86.910
Positive Control Cyclophosphamide 
20         
 50 1039 1422 1.369 28.44 25.5 204.366
Trend: 11.254        
Probability: 0.000