COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01038-0001-0000-5
Chemical Name: 1,2,3-Trichloropropane
CASRN: 96-18-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 539595_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/05/1981    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1044 416 0.398 8.32 25.8 0.000
Test Chemical 1,2,3-Trichloropropane
14.2       
50 1048 401 0.383 8.02 25.8 -3.974
47.2       
50 1046 423 0.404 8.46 25.8 1.488
141.7       
50 1047 420 0.401 8.40 25.8 0.672
472         
0 0 0 0.000 0.00 25.8 N/A
Positive Control Mitomycin-C
5         
50 1050 1270 1.210 25.40 25.8 203.544
Trend: 0.347        
Probability: 0.364        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/05/1981    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1036 411 0.397 8.22 25.8 0.000
Test Chemical 1,2,3-Trichloropropane
1.417     
50 1033 401 0.388 8.02 25.8 -2.150
4.724     
45 921 397 0.431 8.82 25.8 8.655
14.17      
50 1027 530 0.516 10.60 25.8 30.084
47.24      
0 0 0 0.000 0.00 0.0 N/A
142         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
2         
50 1021 1027 1.006 20.54 25.8 153.549
Trend: 4.363        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/13/1981    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1043 469 0.450 9.38 25.5 0.000
Test Chemical 1,2,3-Trichloropropane
39.68      
50 1030 738 0.717 14.76 25.5 59.342
49.6       
50 1033 877 0.849 17.54 25.5 88.804
59.51      
50 1028 864 0.840 17.28 25.5 86.910
Positive Control Cyclophosphamide
20         
50 1039 1422 1.369 28.44 25.5 204.366
Trend: 11.254        
Probability: 0.000