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Study Information
Study Attribute Value
CEBS Accession Number: 002-01038-0002-0000-6
Chemical Name: 1,2,3-Trichloropropane
CASRN: 96-18-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 539595_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #:1   Activation: No Activation    Date: 12/10/1981    Harvest Time: 10.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2,3-Trichloropropane 
870.3       
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
943.7       
 50 3 0.060 6.0 0 0.000 0.0 3 0.060 6.0 0 0.000 0.0 
1020.2       
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1076.9       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 25 0.250 23.0 15 0.150 15.0 8 0.080 8.0 2 0.020 2.0
Trend: -0.557 0.000 -0.557  
Probability: 0.711 0.000 0.711  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/14/1982    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 6.0 5 0.050 5.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 11 0.110 8.0 6 0.060 6.0 4 0.040 3.0 1 0.010 1.0
Test Chemical: 1,2,3-Trichloropropane 
59.5       
 100 135 1.350 26.0 27 0.270 11.0 13 0.130 10.0 95 0.950 14.0 
69.4       
 100 83 0.830 23.0 24 0.240 13.0 17 0.170 13.0 42 0.420 6.0 
79.2       
 50 55 1.100 20.0 13 0.260 12.0 12 0.240 6.0 30 0.600 6.0
Positive Control: Cyclophosphamide 
10         
 50 36 0.720 52.0 18 0.360 32.0 17 0.340 26.0 1 0.020 2.0
Trend: 2.098 1.501 1.497  
Probability: 0.018 0.067 0.067  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/23/1981    Harvest Time: 10.8 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2,3-Trichloropropane 
69.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
75.1       
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
79.4       
 100 5 0.050 4.0 2 0.020 2.0 3 0.030 2.0 0 0.000 0.0 
90.7       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 31 0.620 36.0 20 0.400 30.0 11 0.220 18.0 0 0.000 0.0
Trend: 0.216 1.365 -0.481  
Probability: 0.415 0.086 0.685