Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01038-0009-0000-3 |
Chemical Name: | 1,2,3-Trichloropropane |
CASRN: | 96-18-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 544452 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 103 | 112 | 201 | 65 | 60 |
83 | 79 | 142 | 57 | ||||
99 | 103 | 166 | 56 | ||||
87 | 106 | 162 | 62 | ||||
Test Chemical | 1,2,3-Trichloropropane | 0.0078 | 100 | 119 | 168 | 56 | 64 |
78 | 92 | 155 | 66 | ||||
81 | 90 | 166 | 68 | ||||
0.0156 | 102# | 117 | 130 | 42 | 51 | ||
97 | 111 | 142 | 49 | ||||
93 | 102 | 171 | 62 | ||||
0.0313 | 86 | 108 | 137 | 53 | 71 | ||
92 | 111 | 138 | 50 | ||||
69# | 87 | 229 | 111 | ||||
0.0625 | 79 | 76 | 135 | 57 | 51 | ||
84 | 98 | 114 | 46 | ||||
80 | 89 | 123 | 51 | ||||
0.125 | 99 | 70 | 181 | 61 | 61 | ||
100# | 74 | 187 | 62 | ||||
84 | 75 | 149 | 59 | ||||
0.25 | 90# | 29 | 196 | 73 | 67 | ||
86 | 49 | 159 | 62 | ||||
0.5 | |||||||
Positive Control | Ethyl Methane Sulfonate | 250 | 52# | 35 | 949 | 603 | 671* |
55 | 45 | 1182 | 714 | ||||
54 | 37 | 1133 | 697 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 117 | 133 | 127 | 36 | 46 |
76 | 92 | 115 | 50 | ||||
83 | 92 | 113 | 45 | ||||
97 | 83 | 148 | 51 | ||||
Test Chemical | 1,2,3-Trichloropropane | 0.0156 | 72 | 90 | 81 | 37 | 34 |
70 | 85 | 61 | 29 | ||||
95 | 89 | 105 | 37 | ||||
0.0313 | 68 | 59 | 96 | 47 | 38 | ||
65 | 68 | 70 | 36 | ||||
96 | 75 | 92 | 32 | ||||
0.0625 | 106 | 77 | 129 | 41 | 43 | ||
85 | 70 | 129 | 50 | ||||
72 | 62 | 82 | 38 | ||||
0.125 | 76 | 43 | 118 | 52 | 43 | ||
85 | 75 | 92 | 36 | ||||
87 | 66 | 110 | 42 | ||||
0.25 | 90 | 31 | 111 | 41 | 41 | ||
74 | 25 | 109 | 49 | ||||
99 | 37 | 97 | 33 | ||||
0.5 | 58 | 9 | 140 | 80 | 103* | ||
45 | 8 | 168 | 125 | ||||
Positive Control | Ethyl Methane Sulfonate | 250 | 83 | 45 | 796 | 318 | 379* |
85 | 50 | 1056 | 414 | ||||
81 | 47 | 987 | 405 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 83 | 104 | 78 | 31 | 36 |
116 | 107 | 125 | 36 | ||||
108 | 108 | 111 | 34 | ||||
76 | 81 | 95 | 41 | ||||
Test Chemical | 1,2,3-Trichloropropane | 1.56 | 69 | 106 | 80 | 38 | 32 |
94 | 111 | 91 | 32 | ||||
76 | 98 | 59 | 26 | ||||
3.13 | 66 | 99 | 72 | 37 | 37 | ||
83 | 129 | 91 | 36 | ||||
79 | 124 | 89 | 38 | ||||
6.25 | 77 | 130 | 81 | 35 | 38 | ||
96 | 115 | 122 | 42 | ||||
99 | 124 | 105 | 35 | ||||
12.5 | 91# | 106 | 257 | 95 | 98* | ||
82 | 75 | 228 | 93 | ||||
87 | 107 | 275 | 105 | ||||
25 | 73 | 64 | 546 | 250 | 204* | ||
92 | 79 | 505 | 182 | ||||
89 | 90 | 482 | 181 | ||||
50 | 39 | 12 | 741 | 628 | 612* | ||
44 | 18 | 721 | 550 | ||||
37 | 15 | 734 | 658 | ||||
100 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 89 | 76 | 621 | 233 | 223* |
79 | 63 | 587 | 248 | ||||
91 | 77 | 512 | 189 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 67 | 114 | 66 | 33 | 30 |
77# | 97 | 71 | 31 | ||||
72 | 90 | 56 | 26 | ||||
Test Chemical | 1,2,3-Trichloropropane | 0.01 | 60# | 87 | 85 | 47 | 48* |
55 | 78 | 73 | 44 | ||||
52 | 65 | 79 | 51 | ||||
0.02 | 67# | 70 | 173 | 86 | 97* | ||
55 | 74 | 161 | 98 | ||||
52 | 70 | 169 | 109 | ||||
0.03 | 55 | 57 | 225 | 136 | 124* | ||
78# | 89 | 166 | 71 | ||||
59 | 59 | 294 | 166 | ||||
0.04 | 71# | 47 | 353 | 165 | 258* | ||
56 | 37 | 546 | 328 | ||||
55 | 41 | 464 | 280 | ||||
0.05 | 49 | 24 | 499 | 338 | 346* | ||
57 | 31 | 524 | 307 | ||||
45 | 25 | 532 | 393 | ||||
0.06 | 59 | 26 | 574 | 325 | 440* | ||
36 | 10 | 578 | 543 | ||||
32 | 8 | 436 | 452 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 83# | 92 | 321 | 129 | 136* |
77# | 84 | 329 | 143 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination