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Study Information
Study Attribute Value
CEBS Accession Number: 002-01039-0001-0000-6
Chemical Name: 1,2,4,5-Tetrachlorobenzene
CASRN: 95-94-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 275349_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/22/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1039 393 0.378 7.86 26.5 0.000
Test Chemical 1,2,4,5-Tetrachlorobenzene 
7.65      
 50 1044 468 0.448 9.36 26.5 18.514 
23         
 50 1043 464 0.445 9.28 26.5 17.613 
76         
 50 1048 441 0.421 8.82 26.5 11.250
Positive Control Mitomycin-C 
 0.0025    
 50 1044 578 0.554 11.56 26.5 46.369
Mitomycin-C 
 0.01      
 10 209 164 0.785 16.40 26.5 107.453
Trend: 1.358        
Probability: 0.087        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/22/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1039 429 0.413 8.58 26.0 0.000
Test Chemical 1,2,4,5-Tetrachlorobenzene 
7.65      
 50 1047 442 0.422 8.84 26.0 2.243 
23         
 50 1044 381 0.365 7.62 26.0 -11.614 
76.5       
 50 1050 389 0.370 7.78 26.0 -10.274
Positive Control Cyclophosphamide 
 0.5       
 50 1051 629 0.598 12.58 26.0 44.946
Cyclophosphamide 
2.5       
 10 209 256 1.225 25.60 26.0 196.655
Trend: -2.110        
Probability: 0.983