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Study Information
Study Attribute Value
CEBS Accession Number: 002-01039-0002-0000-7
Chemical Name: 1,2,4,5-Tetrachlorobenzene
CASRN: 95-94-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 275349_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/07/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Acetone 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2,4,5-Tetrachlorobenzene 
15         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
50         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
150         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 18 0.090 8.0 12 0.060 6.0 5 0.025 2.5 1 0.005 1.0
Mitomycin-C 
5         
 50 18 0.360 24.0 11 0.220 20.0 7 0.140 10.0 0 0.000 0.0
Trend: 1.326 1.326 0.000  
Probability: 0.092 0.092 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/07/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Acetone 
0         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: 1,2,4,5-Tetrachlorobenzene 
15         
 200 11 0.055 4.0 3 0.015 1.5 8 0.040 2.5 0 0.000 0.0 
50         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
150         
 200 9 0.045 4.5 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 20 39 1.950 70.0 6 0.300 30.0 13 0.650 45.0 20 1.000 2.0
Trend: -0.203 -0.534 0.078  
Probability: 0.580 0.703 0.469