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Study Information
Study Attribute Value
CEBS Accession Number: 002-01039-0011-0000-7
Chemical Name: 1,2,4,5-Tetrachlorobenzene
CASRN: 95-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 411920_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/28/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
4 5.15 ± 0.261
Test Chemical 1,2,4,5-Tetrachlorobenzene
500         
4 4.32 ± 0.148
 
1000         
4 4.28 ± 0.233
 
2000         
4 4.03 ± 0.153
Positive Control Dimethylbenzanthracene
2.5       
4 8.82 ± 0.525


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/26/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
4 4.52 ± 0.236
Test Chemical 1,2,4,5-Tetrachlorobenzene
125         
4 5.99 ± 0.552
 
250         
4 5.51 ± 0.288
 
500         
4 5.53 ± 0.464
Positive Control Dimethylbenzanthracene
2.5       
4 12.71 ± 1.189


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed