Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01039-0011-0000-7
Chemical Name:	1,2,4,5-Tetrachlorobenzene
CASRN:	95-94-3
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	411920_SCE
Study Result:	Negative

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	10/28/87	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	5.15 ± 0.261
Test Chemical	1,2,4,5-Tetrachlorobenzene	500	4	4.32 ± 0.148
		1000	4	4.28 ± 0.233
		2000	4	4.03 ± 0.153
Positive Control	Dimethylbenzanthracene	2.5	4	8.82 ± 0.525

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	04/26/88	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	4.52 ± 0.236
Test Chemical	1,2,4,5-Tetrachlorobenzene	125	4	5.99 ± 0.552
		250	4	5.51 ± 0.288
		500	4	5.53 ± 0.464
Positive Control	Dimethylbenzanthracene	2.5	4	12.71 ± 1.189

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed