Genetic Toxicology - Rodent Cytogenetics

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01039-0012-0000-8
Chemical Name:	1,2,4,5-Tetrachlorobenzene
CASRN:	95-94-3
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	411920_CA
Study Result:	Negative

View Study Details | View Protocol | Download To Excel


Test Type	Start Date	Sample Time (h)	Species	Sex	Tissue	Protocol	Trend Test P
CA	05/04/88	17	Mouse	Male	Bone Marrow	Intraperitoneal Injection x 1/study, 17 hour	0.3051

Test Group		Dose (mg/kg)	n	Percent Cells w/ Aberrations (Mean ± SEM)	Pairwise P
Positive Control	Dimethylbenzanthracene	100	8	17.25 ± 2.75	0.0000
Test Chemical	1,2,4,5-Tetrachlorobenzene	500	8	1.25 ± 0.53	0.1274
		1000	8	1.25 ± 0.53	0.1274
		2000	8	1.00 ± 0.53	0.2062
Vehicle Control	No Stressor	0	8	0.50 ± 0.33	0.0000


Test Type	Start Date	Sample Time (h)	Species	Sex	Tissue	Protocol	Trend Test P
CA	07/13/88	36	Mouse	Male	Bone Marrow	Intraperitoneal Injection x 1/study, 36 hour	0.1385

Test Group		Dose (mg/kg)	n	Percent Cells w/ Aberrations (Mean ± SEM)	Pairwise P
Positive Control	Dimethylbenzanthracene	50	8	30.00 ± 2.83	0.0000
Test Chemical	1,2,4,5-Tetrachlorobenzene	500	8	2.75 ± 1.31	0.0155
		1000	7	2.29 ± 0.81	0.0405
		2000	8	2.25 ± 0.59	0.0405
Vehicle Control	No Stressor	0	8	0.75 ± 0.75	0.0000

Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed