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Study Information
Study Attribute Value
CEBS Accession Number: 002-01039-0012-0000-8
Chemical Name: 1,2,4,5-Tetrachlorobenzene
CASRN: 95-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 411920_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/04/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3051
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 17.25 ± 2.75 0.0000
Test Chemical 1,2,4,5-Tetrachlorobenzene 
500         
 8 1.25 ± 0.53 0.1274
  
1000         
 8 1.25 ± 0.53 0.1274
  
2000         
 8 1.00 ± 0.53 0.2062
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/13/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1385
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 30.00 ± 2.83 0.0000
Test Chemical 1,2,4,5-Tetrachlorobenzene 
500         
 8 2.75 ± 1.31 0.0155
  
1000         
 7 2.29 ± 0.81 0.0405
  
2000         
 8 2.25 ± 0.59 0.0405
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.75 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed