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Study Information
Study Attribute Value
CEBS Accession Number: 002-01043-0001-0000-1
Chemical Name: 1,2-Dibromo-3-chloropropane
CASRN: 96-12-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 019787_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/14/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 449 0.435 8.98 26.5 0.000
Test Chemical 1,2-Dibromo-3-chloropropane 
9.95      
 50 1035 739 0.714 14.78 26.5 64.111 
29.9       
 50 1033 1047 1.014 20.94 26.5 132.959 
99.5       
 10 208 620 2.981 62.00 30.5 585.112
Positive Control Mitomycin-C 
 0.0015    
 50 1039 642 0.618 12.84 26.5 42.021
Mitomycin-C 
 0.01      
 10 208 358 1.721 35.80 26.5 295.597
Trend: 30.112        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/27/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 480 0.458 9.60 26.5 0.000
Test Chemical 1,2-Dibromo-3-chloropropane 
50         
 10 211 428 2.028 42.80 26.5 343.298 
75         
 10 211 534 2.531 53.40 26.5 453.086 
100         
 10 207 653 3.155 65.30 26.5 589.409
Positive Control Mitomycin-C 
 0.002     
 50 1048 800 0.763 16.00 26.5 66.826
Mitomycin-C 
 0.01      
 10 211 333 1.578 33.30 26.5 244.902
Trend: 38.014        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/14/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 481 0.462 9.62 25.5 0.000
Test Chemical 1,2-Dibromo-3-chloropropane 
9.95      
 50 1039 708 0.681 14.16 25.5 47.618 
29.9       
 50 1051 1319 1.255 26.38 25.5 171.872 
99.5       
 10 211 481 2.280 48.10 29.5 393.839
Positive Control Cyclophosphamide 
 0.5       
 50 1044 838 0.803 16.76 25.5 73.887
Cyclophosphamide 
2.5       
 10 212 352 1.660 35.20 25.5 259.691
Trend: 27.928        
Probability: 0.000