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Study Information
Study Attribute Value
CEBS Accession Number: 002-01043-0002-0000-2
Chemical Name: 1,2-Dibromo-3-chloropropane
CASRN: 96-12-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 019787_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/11/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Dibromo-3-chloropropane 
50         
 100 10 0.100 8.0 4 0.040 3.0 6 0.060 5.0 0 0.000 0.0 
150         
 100 7 0.070 7.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 50 33 0.660 42.0 22 0.440 32.0 11 0.220 18.0 0 0.000 0.0
Trend: 1.629 0.612 1.545  
Probability: 0.052 0.270 0.061  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/11/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 10 0.100 1.0 0 0.000 0.0 0 0.000 0.0 10 0.100 1.0
Test Chemical: 1,2-Dibromo-3-chloropropane 
10         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
50         
 100 18 0.180 14.0 9 0.090 7.0 9 0.090 8.0 0 0.000 0.0 
150         
 100 30 0.300 18.0 9 0.090 8.0 21 0.210 13.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 33 0.660 42.0 17 0.340 24.0 16 0.320 24.0 0 0.000 0.0
Trend: 4.607 3.714 3.780  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 12/20/1984    Harvest Time: 18.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Dibromo-3-chloropropane 
150         
 100 45 0.450 19.0 16 0.160 14.0 9 0.090 8.0 20 0.200 2.0 
299         
 100 48 0.480 33.0 17 0.170 14.0 31 0.310 22.0 0 0.000 0.0 
499         
 100 83 0.830 42.0 28 0.280 24.0 55 0.550 36.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 15 110 7.333 100.0 5 0.333 27.0 4 0.267 13.0 101 6.733 11.0
Trend: 7.411 4.730 7.328  
Probability: 0.000 0.000 0.000