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Study Information
Study Attribute Value
CEBS Accession Number: 002-01043-0015-0000-6
Chemical Name: 1,2-Dibromo-3-chloropropane
CASRN: 96-12-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 063691
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 83 70 145 58 54
    96 96 176 61
    85 92 135 53
    87 142 116 44
Test Chemical 1,2-Dibromo-3-chloropropane 
10         
 88 91 191 73 67
    107 105 166 52
    75 84 173 77
  
20         
 75 57 140 63 72
    91 66 208 76
    78 54 178 76
  
30         
 92 53 171 62 76
    86 54 210 82
    72 39 177 83
  
40         
 76 26 329 145 131*
    81 23 309 128
    65 25 235 120
  
60         
 52 9 368 237 211*
    61# 14 409 222
    61 14 318 173
  
80         
 47 5 293 209 227*
    29 3 199 227
    31 4 225 246
  
120         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 61 51 463 252 293*
    57 39 568 334
    48# 29 426 294

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 90 90 146 54 47
    110 111 143 43
    97 99 128 44
Test Chemical 1,2-Dibromo-3-chloropropane 
10         
 115# 74 197 57 59
    118# 90 177 50
    88 56 183 69
  
20         
 125r 60 117 31 51
    111# 40 132 40
    113 50 211 62
  
30         
 106 32 170 53 58
    77 28 158 68
    101 34 161 53
  
40         
 119 11 409 115 109*
    88 18 227 86
    110 15 418 127
  
60         
 60 5 435 242 202*
    90 7 504 187
    92# 7 485 176
  
80         
   
  
120         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 103 63 671 218 172*
    103 81 388 126

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination