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Study Information
Study Attribute Value
CEBS Accession Number: 002-01043-0016-0000-7
Chemical Name: 1,2-Dibromo-3-chloropropane
CASRN: 96-12-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 063791_SCE
Study Result: Equivocal


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/10/85 17 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  17 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.73 ± 0.366
Test Chemical 1,2-Dibromo-3-chloropropane 
25         
 4 4.85 ± 0.375
  
50         
 4 5.57 ± 0.492
  
100         
 4 5.58 ± 0.365
Positive Control Dimethylbenzanthracene 
100         
 4 10.41 ± 0.191


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/20/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.56 ± 0.405
Test Chemical 1,2-Dibromo-3-chloropropane 
25         
 4 6.32 ± 0.624
  
50         
 4 4.95 ± 0.102
  
100         
 4 6.52 ± 0.661
Positive Control Dimethylbenzanthracene 
2.5       
 4 10.59 ± 0.688


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/30/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.65 ± 0.462
Test Chemical 1,2-Dibromo-3-chloropropane 
25         
 4 4.72 ± 0.829
  
50         
 4 5.03 ± 1.035
  
100         
 4 5.59 ± 1.111
Positive Control Dimethylbenzanthracene 
2.5       
 4 11.12 ± 0.651


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed