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Study Information
Study Attribute Value
CEBS Accession Number: 002-01044-0002-0000-3
Chemical Name: 1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane
CASRN: 3322-93-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 027958_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/29/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane
10         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
30         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
100         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C
5         
50 40 0.800 48.0 21 0.420 32.0 19 0.380 26.0 0 0.000 0.0
Trend: -0.216 0.419 -0.451  
Probability: 0.586 0.338 0.674  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/19/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane
30         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
100         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
150         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
300         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
50 27 0.540 38.0 12 0.240 20.0 14 0.280 24.0 1 0.020 1.0
Trend: 0.360 0.000 0.360  
Probability: 0.359 0.000 0.359