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Study Information
Study Attribute Value
CEBS Accession Number: 002-01045-0001-0000-3
Chemical Name: 1,2-Dibromoethane
CASRN: 106-93-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 665769_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/16/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 402 0.396 8.04 25.5 0.000
Test Chemical 1,2-Dibromoethane 
5         
 50 1009 715 0.709 14.30 25.5 79.095 
16.7       
 10 202 265 1.312 26.50 25.5 231.560 
50         
 10 203 264 1.300 26.40 25.5 228.682 
166.7       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1031 527 0.511 10.54 25.5 29.187
Mitomycin-C 
 0.01      
 5 103 221 2.146 44.20 25.5 442.279
Trend: 18.368        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/01/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 515 233 0.452 9.32 25.5 0.000
Test Chemical 1,2-Dibromoethane 
14.9       
 25 504 438 0.869 17.52 25.5 92.086 
49.6       
 5 103 122 1.184 24.40 25.5 161.803 
150.4       
 5 104 219 2.106 43.80 25.5 365.438 
501.2       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 25 505 271 0.537 10.84 25.5 18.612
Mitomycin-C 
 0.01      
 5 104 154 1.481 30.80 25.5 227.294
Trend: 17.200        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/16/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 458 0.448 9.16 25.5 0.000
Test Chemical 1,2-Dibromoethane 
5         
 50 1027 552 0.537 11.04 25.5 19.937 
16.7       
 50 1018 909 0.893 18.18 25.5 99.251 
50         
 10 199 250 1.256 25.00 25.5 180.332 
166.6       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1023 797 0.779 15.94 25.5 73.847
Cyclophosphamide 
2         
 5 101 205 2.030 41.00 25.5 352.916
Trend: 16.007        
Probability: 0.000