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Study Information
Study Attribute Value
CEBS Accession Number: 002-01045-0002-0000-4
Chemical Name: 1,2-Dibromoethane
CASRN: 106-93-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 665769_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 09/04/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: 1,2-Dibromoethane 
250.6       
 200 70 0.350 18.0 23 0.115 10.0 24 0.120 10.0 23 0.115 2.0 
375.9       
 25 21 0.840 40.0 13 0.520 32.0 8 0.320 32.0 0 0.000 0.0 
501.2       
 25 25 1.000 48.0 14 0.560 36.0 10 0.400 28.0 1 0.040 4.0
Positive Control: Mitomycin-C 
 0.05      
 200 46 0.230 19.0 13 0.065 6.0 33 0.165 13.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 10 0.400 36.0 2 0.080 8.0 8 0.320 28.0 0 0.000 0.0
Trend: 8.433 7.813 6.556  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/04/1985    Harvest Time: 20.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 3 0.015 2.0 1 0.005 1.0
Test Chemical: 1,2-Dibromoethane 
49.6       
 200 5 0.025 3.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
99.6       
 200 9 0.045 3.0 4 0.020 2.0 5 0.025 2.0 0 0.000 0.0 
150.4       
 93 49 0.527 24.0 27 0.290 18.0 19 0.204 13.0 3 0.032 3.0 
199.2       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 18 0.090 7.0 4 0.020 2.0 14 0.070 6.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 9 0.360 32.0 2 0.080 8.0 7 0.280 24.0 0 0.000 0.0
Trend: 5.518 6.191 3.346  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 10/10/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Dibromoethane 
375.8       
 25 35 1.400 56.0 16 0.640 48.0 9 0.360 32.0 10 0.400 4.0 
501         
 25 36 1.440 48.0 13 0.520 36.0 3 0.120 12.0 20 0.800 8.0 
751.5       
 25 44 1.760 56.0 2 0.080 8.0 22 0.880 44.0 20 0.800 8.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 24 0.240 20.0 11 0.110 11.0 13 0.130 10.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 14 0.560 40.0 6 0.240 20.0 8 0.320 24.0 0 0.000 0.0
Trend: 7.047 2.805 5.811  
Probability: 0.000 0.003 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/10/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Dibromoethane 
124.5       
 100 18 0.180 10.0 8 0.080 5.0 10 0.100 7.0 0 0.000 0.0 
149.4       
 25 47 1.880 68.0 15 0.600 44.0 22 0.880 44.0 10 0.400 4.0 
175.4       
 25 35 1.400 56.0 17 0.680 40.0 18 0.720 48.0 0 0.000 0.0 
199.2       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 10 0.100 10.0 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 13 0.520 36.0 5 0.200 16.0 8 0.320 28.0 0 0.000 0.0
Trend: 8.539 7.184 7.651  
Probability: 0.000 0.000 0.000