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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0001-0000-4
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 059536_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/15/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 332 0.318 6.64 26.0 0.000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
5.9       
 50 1048 345 0.329 6.90 26.0 3.618 
19.7       
 50 1048 317 0.302 6.34 26.0 -4.791 
59         
 50 1047 330 0.315 6.60 26.0 -0.792
Positive Control Mitomycin-C 
 0.0015    
 50 1052 569 0.541 11.38 26.0 70.245
Mitomycin-C 
 0.01      
 10 208 334 1.606 33.40 26.0 405.430
Trend: -0.456        
Probability: 0.676        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/15/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 363 0.348 7.26 26.0 0.000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
19.7       
 50 1042 432 0.415 8.64 26.0 19.008 
59         
 50 1048 449 0.428 8.98 26.0 22.983 
197         
 50 1042 445 0.427 8.90 26.0 22.590
Positive Control Cyclophosphamide 
 0.4       
 50 1040 681 0.655 13.62 26.0 87.964
Cyclophosphamide 
2.5       
 10 210 353 1.681 35.30 26.0 382.521
Trend: 2.824        
Probability: 0.002        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/11/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 424 0.406 8.48 26.0 0.000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
300         
 50 1048 534 0.510 10.68 26.0 25.463 
400         
 50 1048 519 0.495 10.38 26.0 21.938 
500         
 50 1048 503 0.480 10.06 26.0 18.179
Positive Control Cyclophosphamide 
 0.4       
 50 1048 745 0.711 14.90 26.0 75.037
Cyclophosphamide 
2.5       
 10 208 403 1.938 40.30 26.0 377.064
Trend: 2.205        
Probability: 0.014