| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01046-0014-0000-8 |
| Chemical Name: | 1,2-Dichlorobenzene (o-dichlorobenzene) |
| CASRN: | 95-50-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 388032_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 12/09/85 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.17 ± 0.388 | |
| Test Chemical | 1,2-Dichlorobenzene (o-dichlorobenzene) | 200 | 4 | 2.75 ± 0.398 | |
400 | 4 | 4.61 ± 0.286 | |||
800 | 4 | 4.06 ± 0.446 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 8.85 ± 0.716 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 06/30/87 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.65 ± 0.462 | |
| Test Chemical | 1,2-Dichlorobenzene (o-dichlorobenzene) | 175 | 4 | 4.12 ± 0.208 | |
350 | 4 | 3.60 ± 0.288 | |||
700 | 4 | 3.15 ± 0.157 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 11.12 ± 0.651 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed