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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0014-0000-8
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 388032_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/09/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
4 4.17 ± 0.388
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene)
200         
4 2.75 ± 0.398
 
400         
4 4.61 ± 0.286
 
800         
4 4.06 ± 0.446
Positive Control Dimethylbenzanthracene
2.5       
4 8.85 ± 0.716


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/30/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
4 4.65 ± 0.462
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene)
175         
4 4.12 ± 0.208
 
350         
4 3.60 ± 0.288
 
700         
4 3.15 ± 0.157
Positive Control Dimethylbenzanthracene
2.5       
4 11.12 ± 0.651


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed