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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0015-0000-9
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 388032_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/10/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6793
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 12.00 ± 1.77 0.0000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
200         
 8 3.50 ± 1.05 0.1451
  
400         
 8 1.75 ± 0.80 0.6932
  
800         
 8 2.25 ± 1.16 0.5000
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.96 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/10/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0017
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 32.75 ± 5.57 0.0000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
200         
 7 4.00 ± 1.38 0.7909
  
400         
 8 3.25 ± 0.92 0.9196
  
800         
 8 9.50 ± 1.84 0.0107
Vehicle Control No Stressor 
 0         
 8 5.25 ± 1.06 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/02/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0094
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 18.75 ± 2.70 0.0000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
400         
 8 2.75 ± 0.75 0.3253
  
600         
 8 4.00 ± 0.85 0.0775
  
800         
 8 5.25 ± 1.46 0.0128
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.45 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed