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Study Information
Study Attribute Value
CEBS Accession Number: 002-01046-0016-0000-0
Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: 95-50-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 732739_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/21/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1768
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 7.75 ± 1.58 0.0000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
375         
 8 1.50 ± 0.50 0.5000
  
750         
 8 2.00 ± 0.93 0.2949
  
1500         
 7 2.29 ± 0.68 0.2138
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/29/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4711
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.75 ± 3.94 0.0000
Test Chemical 1,2-Dichlorobenzene (o-dichlorobenzene) 
150         
 8 1.75 ± 0.59 0.1812
  
300         
 8 1.50 ± 0.82 0.2622
  
600         
 8 1.25 ± 0.84 0.3687
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed