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Study Information
Study Attribute Value
CEBS Accession Number: 002-01047-0001-0000-5
Chemical Name: 1,2-Dichloroethane
CASRN: 107-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 756073_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/16/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 510 0.487 10.20 25.5 0.000
Test Chemical 1,2-Dichloroethane 
502.8       
 50 1035 752 0.727 15.04 25.5 49.161 
1700         
 50 1042 1174 1.127 23.48 25.5 131.301 
5000         
 25 514 845 1.644 33.80 30.2 237.497
Positive Control Mitomycin-C 
 0.001     
 50 1041 538 0.517 10.76 25.5 6.098
Mitomycin-C 
 0.01      
 5 104 198 1.904 39.60 25.5 290.848
Trend: 24.217        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/16/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 419 0.406 8.38 25.5 0.000
Test Chemical 1,2-Dichloroethane 
16.8       
 50 1031 461 0.447 9.22 25.5 10.237 
50.3       
 50 1037 478 0.461 9.56 25.5 13.641 
167.6       
 50 1036 583 0.563 11.66 25.5 38.738 
502.8       
 0 0 0 0.000 0.00 30.2 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 630 0.609 12.60 25.5 50.067
Cyclophosphamide 
2         
 5 104 194 1.865 38.80 25.5 359.891
Trend: 5.129        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/04/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 520 201 0.387 8.04 25.5 0.000
Test Chemical 1,2-Dichloroethane 
278.7       
 25 520 318 0.612 12.72 25.5 58.209 
387.1       
 25 517 339 0.656 13.56 25.5 69.635 
502.7       
 25 514 392 0.763 15.68 32.8 97.301
Positive Control Cyclophosphamide 
 0.4       
 25 522 308 0.590 12.32 25.5 52.647
Cyclophosphamide 
2         
 5 103 147 1.427 29.40 25.5 269.222
Trend: 7.661        
Probability: 0.000