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Study Information
Study Attribute Value
CEBS Accession Number: 002-01047-0002-0000-6
Chemical Name: 1,2-Dichloroethane
CASRN: 107-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 756073_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/12/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: 1,2-Dichloroethane 
3736         
 100 7 0.070 7.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
4395         
 100 6 0.060 6.0 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 
4994         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 50 0.500 37.0 13 0.130 12.0 34 0.340 27.0 3 0.030 3.0
Mitomycin-C 
 0.08      
 25 30 1.200 60.0 11 0.440 40.0 19 0.760 32.0 0 0.000 0.0
Trend: 1.049 -0.127 1.963  
Probability: 0.147 0.550 0.025  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/12/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 0 0.000 0.0 4 0.040 4.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: 1,2-Dichloroethane 
750         
 50 63 1.260 66.0 25 0.500 40.0 38 0.760 40.0 0 0.000 0.0 
1000         
 50 76 1.520 78.0 19 0.380 30.0 57 1.140 64.0 0 0.000 0.0 
1250         
 50 111 2.220 86.0 14 0.280 22.0 77 1.540 76.0 20 0.400 4.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.3       
 100 7 0.070 7.0 3 0.030 3.0 4 0.040 4.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 16 0.640 40.0 7 0.280 24.0 9 0.360 24.0 0 0.000 0.0
Trend: 10.634 3.620 10.004  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 10/28/1986    Harvest Time: 20.1 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Dichloroethane 
3771         
 200 9 0.045 4.5 6 0.030 3.0 2 0.010 1.0 1 0.005 0.5 
5028         
 200 13 0.065 4.0 5 0.025 2.5 8 0.040 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 25 0.125 8.5 11 0.055 4.5 13 0.065 5.0 1 0.005 0.5
Mitomycin-C 
 0.08      
 25 9 0.360 36.0 4 0.160 16.0 5 0.200 20.0 0 0.000 0.0
Trend: 0.643 0.191 2.151  
Probability: 0.260 0.424 0.016  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/28/1986    Harvest Time: 20.1 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Dichloroethane 
500         
 100 9 0.090 9.0 5 0.050 5.0 4 0.040 4.0 0 0.000 0.0 
1000         
 25 23 0.920 56.0 8 0.320 28.0 14 0.560 36.0 1 0.040 4.0 
1493         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.3       
 200 20 0.100 9.0 8 0.040 4.0 12 0.060 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 17 0.680 32.0 3 0.120 12.0 14 0.560 28.0 0 0.000 0.0
Trend: 9.019 6.025 7.484  
Probability: 0.000 0.000 0.000