COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01048-0001-0000-6
Chemical Name: 1,2-Dichloropropane (propylene dichloride)
CASRN: 78-87-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 903632_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/05/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 497 0.479 9.94 25.8 0.000
Test Chemical 1,2-Dichloropropane (propylene dichloride) 
112.7       
 50 1034 620 0.600 12.40 25.8 25.110 
376         
 50 1019 1029 1.010 20.58 25.8 110.700 
1127         
 50 1041 1794 1.723 35.88 34.8 259.579
Positive Control Mitomycin-C 
 0.01      
 25 908 521 0.574 20.84 25.8 19.722
Trend: 30.477        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/05/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1013 439 0.433 8.78 25.5 0.000
Test Chemical 1,2-Dichloropropane (propylene dichloride) 
112.7       
 50 1038 531 0.512 10.62 25.5 18.044 
376         
 50 1022 895 0.876 17.90 25.5 102.077 
1127         
 50 1025 1080 1.054 21.60 34.5 143.134
Positive Control Cyclophosphamide 
1.5       
 25 510 668 1.310 26.72 25.5 202.239
Trend: 18.802        
Probability: 0.000