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Study Information
Study Attribute Value
CEBS Accession Number: 002-01048-0002-0000-7
Chemical Name: 1,2-Dichloropropane (propylene dichloride)
CASRN: 78-87-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 903632_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 02/02/1982    Harvest Time: 19.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Dichloropropane (propylene dichloride) 
1180         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1370         
 100 16 0.160 11.0 11 0.110 9.0 5 0.050 5.0 0 0.000 0.0 
1580         
 100 47 0.470 26.0 22 0.220 21.0 15 0.150 9.0 10 0.100 1.0
Positive Control: Mitomycin-C 
 0.125     
 50 51 1.020 50.0 26 0.520 40.0 15 0.300 22.0 10 0.200 2.0
Trend: 5.547 4.961 3.421  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/13/1982    Harvest Time: 10 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 13 0.130 4.0 3 0.030 3.0 0 0.000 0.0 10 0.100 1.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 2.0 1 0.010 1.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: 1,2-Dichloropropane (propylene dichloride) 
460         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0 
660         
 100 17 0.170 15.0 8 0.080 8.0 9 0.090 9.0 0 0.000 0.0 
950         
 100 16 0.160 13.0 8 0.080 8.0 7 0.070 6.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 50 23 0.460 24.0 12 0.240 22.0 11 0.220 14.0 0 0.000 0.0
Trend: 3.788 3.212 2.370  
Probability: 0.000 0.001 0.009  


Trial #:2   Activation: No Activation    Date: 01/13/1982    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 19 0.190 8.0 1 0.010 1.0 4 0.040 4.0 14 0.140 5.0
Dimethyl Sulfoxide 
0         
 100 10 0.100 9.0 0 0.000 0.0 8 0.080 8.0 2 0.020 2.0
Test Chemical: 1,2-Dichloropropane (propylene dichloride) 
660         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
950         
 100 5 0.050 3.0 4 0.040 2.0 1 0.010 1.0 0 0.000 0.0 
1350         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 50 25 0.500 28.0 10 0.200 16.0 13 0.260 18.0 2 0.040 4.0
Trend: -2.674 0.650 -2.875  
Probability: 0.996 0.258 0.998