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Study Information
Study Attribute Value
CEBS Accession Number: 002-01048-0013-0000-9
Chemical Name: 1,2-Dichloropropane (propylene dichloride)
CASRN: 78-87-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 568899_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/28/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7866
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 14.25 ± 2.09 0.0000
Test Chemical 1,2-Dichloropropane (propylene dichloride) 
112.5       
 8 2.25 ± 0.45 0.8064
  
225         
 8 2.00 ± 0.76 0.8656
  
450         
 8 2.25 ± 1.33 0.8064
Vehicle Control No Stressor 
 0         
 8 3.25 ± 1.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/08/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0033
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 36.00 ± 3.25 0.0000
Test Chemical 1,2-Dichloropropane (propylene dichloride) 
112.5       
 8 0.75 ± 0.37 0.5000
  
225         
 7 0.86 ± 0.40 0.4347
  
450         
 8 2.75 ± 1.31 0.0155
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/19/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.8878
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 22.75 ± 4.03 0.0000
Test Chemical 1,2-Dichloropropane (propylene dichloride) 
225         
 8 3.00 ± 0.85 0.1825
  
335         
 8 2.50 ± 0.91 0.3168
  
450         
 8 0.50 ± 0.33 0.9719
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.76 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed