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Study Information
Study Attribute Value
CEBS Accession Number: 002-01051-0001-0000-0
Chemical Name: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer)
CASRN: 147-47-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 677113_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Test Failure 
No Activation  3  Positive 
No Activation  4  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Test Failure 
Induced Rat Liver S9  3_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/06/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 531 0.512 10.62 26.0 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
9.61      
 50 1041 546 0.524 10.92 26.0 2.529 
32         
 0 0 0 0.000 0.00 33.2 N/A 
96.1       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1041 767 0.737 15.34 26.0 44.028
Mitomycin-C 
 0.01      
 5 106 278 2.623 55.60 26.0 412.675
Trend: 0.410        
Probability: 0.341        

Trial #: 2    Activation: No Activation    Date: 01/31/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 525 0.500 10.50 26.0 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
40         
 50 1040 556 0.535 11.12 26.0 6.821
Positive Control Mitomycin-C 
 0.0015    
 50 1048 809 0.772 16.18 26.0 54.242
Mitomycin-C 
 0.01      
 5 104 194 1.865 38.80 26.0 272.722
Trend: 0.000        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 02/27/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 529 0.504 10.58 26.3 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
40         
 50 1050 765 0.729 15.30 34.2 44.475 
50         
 50 1050 633 0.603 12.66 34.2 19.546 
60         
 50 1048 680 0.649 13.60 34.2 28.667 
70         
 0 0 0 0.000 0.00 34.2 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1047 800 0.764 16.00 26.3 51.518
Mitomycin-C 
 0.01      
 5 105 237 2.257 47.40 26.3 347.588
Trend: 2.658        
Probability: 0.004        

Trial #: 4    Activation: No Activation    Date: 03/07/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 403 0.385 8.06 26.0 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
40         
 50 1050 507 0.483 10.14 34.3 25.567 
50         
 50 1045 484 0.463 9.68 34.3 20.444 
60         
 50 1050 576 0.549 11.52 34.3 42.656 
70         
 0 0 0 0.000 0.00 34.3 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1050 702 0.669 14.04 26.0 73.862
Mitomycin-C 
 0.01      
 5 105 233 2.219 46.60 26.0 477.063
Trend: 4.898        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/06/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 545 0.522 10.90 26.0 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
9.61      
 50 1051 494 0.470 9.88 26.0 -9.875 
32         
 50 1044 656 0.628 13.12 26.0 20.482 
96.1       
 50 1047 646 0.617 12.92 33.2 18.306 
320         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.8       
 25 526 502 0.954 20.08 26.0 82.994
Cyclophosphamide 
2         
 5 104 265 2.548 53.00 26.0 388.576
Trend: 4.336        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/31/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 25 526 371 0.705 14.84 26.0 -11.369
Dimethyl Sulfoxide 
0         
 50 1048 834 0.796 16.68 26.0 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
60         
 50 1046 689 0.659 13.78 26.0 -17.228 
80         
 50 1045 837 0.801 16.74 32.8 0.648 
100         
 50 1048 864 0.824 17.28 32.8 3.597 
120         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1047 993 0.948 19.86 26.0 19.178
Cyclophosphamide 
2         
 5 106 277 2.613 55.40 26.0 228.374
Trend: 2.015        
Probability: 0.022        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 02/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 626 0.596 12.52 26.3 9.162
Dimethyl Sulfoxide 
0         
 50 1040 568 0.546 11.36 26.3 0.000
Test Chemical 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
60         
 50 1050 571 0.544 11.42 26.3 -0.429 
80         
 50 1047 593 0.566 11.86 26.3 3.703 
100         
 50 1049 588 0.561 11.76 26.3 2.633 
120         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1050 868 0.827 17.36 26.3 51.362
Cyclophosphamide 
2         
 5 105 246 2.343 49.20 26.3 328.974
Trend: 0.663        
Probability: 0.254