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Study Information
Study Attribute Value
CEBS Accession Number: 002-01051-0002-0000-1
Chemical Name: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer)
CASRN: 147-47-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 677113_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/20/1984    Harvest Time: 23.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 4.0 1 0.010 1.0 3 0.030 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 3.0 1 0.010 1.0 3 0.030 2.0 1 0.010 1.0
Test Chemical: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
70         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
80         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
100         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0 
120         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.035     
 100 19 0.190 17.0 8 0.080 8.0 9 0.090 8.0 2 0.020 2.0
Mitomycin-C 
 0.0625    
 25 12 0.480 36.0 5 0.200 16.0 6 0.240 16.0 1 0.040 4.0
Trend: 0.402 -1.213 1.132  
Probability: 0.344 0.887 0.129  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/28/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) 
70         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
80         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
100         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
120         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 100 19 0.190 10.0 2 0.020 2.0 6 0.060 6.0 11 0.110 2.0
Cyclophosphamide 
20         
 25 13 0.520 40.0 8 0.320 32.0 5 0.200 16.0 0 0.000 0.0
Trend: 0.790 1.034 0.423  
Probability: 0.215 0.151 0.336