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Study Information
Study Attribute Value
CEBS Accession Number: 002-01055-0001-0000-4
Chemical Name: 1,2-Epoxy-3,3,3-trichloropropane
CASRN: 3083-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 800706_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1021 550 0.539 11.00 26.0 0.000
Test Chemical 1,2-Epoxy-3,3,3-trichloropropane 
 0.5       
 50 1033 907 0.878 18.14 26.0 62.993 
2         
 50 1030 1048 1.017 20.96 26.0 88.880 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1037 616 0.594 12.32 26.0 10.272
Mitomycin-C 
 0.01      
 5 105 235 2.238 47.00 26.0 315.472
Trend: 11.849        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 414 0.402 8.28 26.0 0.000
Test Chemical 1,2-Epoxy-3,3,3-trichloropropane 
 0.5       
 50 1028 500 0.486 10.00 26.0 21.008 
1         
 50 1024 555 0.542 11.10 26.0 34.843 
2         
 14 286 189 0.661 13.50 26.0 64.412 
3         
 13 267 173 0.648 13.31 26.0 61.202 
4         
 50 1046 1276 1.220 25.52 33.0 203.498 
5         
 0 0 0 0.000 0.00 33.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1023 568 0.555 11.36 26.0 38.137
Mitomycin-C 
 0.01      
 5 104 160 1.538 32.00 26.0 282.757
Trend: 23.094        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 511 0.496 10.22 26.0 0.000
Test Chemical 1,2-Epoxy-3,3,3-trichloropropane 
 0.5       
 50 1026 533 0.519 10.66 26.0 4.814 
2         
 50 1039 648 0.624 12.96 26.0 25.834 
5         
 50 1033 958 0.927 19.16 26.0 87.113 
15         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 634 0.613 12.68 26.0 23.591
Cyclophosphamide 
2         
 5 104 160 1.538 32.00 26.0 210.402
Trend: 12.209        
Probability: 0.000