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Study Information
Study Attribute Value
CEBS Accession Number: 002-01055-0002-0000-5
Chemical Name: 1,2-Epoxy-3,3,3-trichloropropane
CASRN: 3083-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 800706_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/05/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
8         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
10         
 100 7 0.070 6.0 5 0.050 5.0 2 0.020 2.0 0 0.000 0.0 
12         
 100 6 0.060 5.0 3 0.030 3.0 3 0.030 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 11 0.110 10.0 6 0.060 5.0 5 0.050 5.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 50 16 0.320 24.0 8 0.160 12.0 8 0.160 12.0 0 0.000 0.0
Trend: 2.190 2.022 1.026  
Probability: 0.014 0.022 0.153  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/19/1984    Harvest Time: 12.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 8 0.080 7.0 3 0.030 2.0 5 0.050 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
8         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
10         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
20         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
30         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 13 0.130 12.0 5 0.050 5.0 8 0.080 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 8 0.320 32.0 3 0.120 3.0 5 0.200 5.0 0 0.000 0.0
Trend: 1.501 0.567 1.474  
Probability: 0.067 0.285 0.070  


Trial #:2   Activation: No Activation    Date: 01/30/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
10         
 100 9 0.090 7.0 4 0.040 4.0 5 0.050 4.0 0 0.000 0.0 
15         
 100 26 0.260 17.0 7 0.070 6.0 19 0.190 13.0 0 0.000 0.0 
20         
 50 36 0.720 44.0 11 0.220 8.0 25 0.500 8.0 0 0.000 0.0 
25         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 19 0.190 15.0 12 0.120 9.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.625     
 25 8 0.320 32.0 1 0.040 4.0 7 0.280 28.0 0 0.000 0.0
Trend: 7.253 2.628 3.401  
Probability: 0.000 0.004 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/30/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
25         
 25 27 1.080 52.0 12 0.480 32.0 15 0.600 32.0 0 0.000 0.0 
30         
 25 22 0.880 52.0 14 0.560 36.0 8 0.320 24.0 0 0.000 0.0 
35         
 25 21 0.840 48.0 12 0.480 28.0 9 0.360 36.0 0 0.000 0.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 13 0.520 40.0 5 0.200 16.0 8 0.320 24.0 0 0.000 0.0
Trend: 6.485 5.150 4.863  
Probability: 0.000 0.000 0.000