Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01055-0002-0000-5
Chemical Name: 1,2-Epoxy-3,3,3-trichloropropane
CASRN: 3083-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 800706_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/05/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
8         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
10         
 100 7 0.070 6.0 5 0.050 5.0 2 0.020 2.0 0 0.000 0.0 
12         
 100 6 0.060 5.0 3 0.030 3.0 3 0.030 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 11 0.110 10.0 6 0.060 5.0 5 0.050 5.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 50 16 0.320 24.0 8 0.160 12.0 8 0.160 12.0 0 0.000 0.0
Trend: 2.190 2.022 1.026  
Probability: 0.014 0.022 0.153  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/19/1984    Harvest Time: 12.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 8 0.080 7.0 3 0.030 2.0 5 0.050 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
8         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
10         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
20         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
30         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 13 0.130 12.0 5 0.050 5.0 8 0.080 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 8 0.320 32.0 3 0.120 3.0 5 0.200 5.0 0 0.000 0.0
Trend: 1.501 0.567 1.474  
Probability: 0.067 0.285 0.070  


Trial #:2   Activation: No Activation    Date: 01/30/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
10         
 100 9 0.090 7.0 4 0.040 4.0 5 0.050 4.0 0 0.000 0.0 
15         
 100 26 0.260 17.0 7 0.070 6.0 19 0.190 13.0 0 0.000 0.0 
20         
 50 36 0.720 44.0 11 0.220 8.0 25 0.500 8.0 0 0.000 0.0 
25         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 19 0.190 15.0 12 0.120 9.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.625     
 25 8 0.320 32.0 1 0.040 4.0 7 0.280 28.0 0 0.000 0.0
Trend: 7.253 2.628 3.401  
Probability: 0.000 0.004 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/30/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
25         
 25 27 1.080 52.0 12 0.480 32.0 15 0.600 32.0 0 0.000 0.0 
30         
 25 22 0.880 52.0 14 0.560 36.0 8 0.320 24.0 0 0.000 0.0 
35         
 25 21 0.840 48.0 12 0.480 28.0 9 0.360 36.0 0 0.000 0.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 13 0.520 40.0 5 0.200 16.0 8 0.320 24.0 0 0.000 0.0
Trend: 6.485 5.150 4.863  
Probability: 0.000 0.000 0.000