COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01055-0003-0000-6
Chemical Name: 1,2-Epoxy-3,3,3-trichloropropane
CASRN: 3083-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 919832_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 02/06/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 431 0.410 8.62 26.0 0.000
Test Chemical 1,2-Epoxy-3,3,3-trichloropropane 
 0.16      
 50 1047 450 0.430 9.00 26.0 4.708 
 0.5       
 50 1050 616 0.587 12.32 26.0 42.923 
1.6       
 50 1048 703 0.671 14.06 26.0 63.420 
5         
 50 1051 1095 1.042 21.90 26.0 153.819 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 581 0.553 11.62 26.0 34.675
Mitomycin-C 
 0.005     
 10 210 282 1.343 28.20 26.0 227.146
Trend: 19.436        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/13/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 443 0.422 8.86 26.5 0.000
Test Chemical 1,2-Epoxy-3,3,3-trichloropropane 
1         
 50 1050 599 0.570 11.98 26.5 35.214 
1.6       
 50 1049 815 0.777 16.30 26.5 84.148 
3         
 50 1051 889 0.846 17.78 26.5 100.486 
5         
 50 1054 1335 1.267 26.70 26.5 200.211
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 568 0.542 11.36 26.5 28.461
Mitomycin-C 
 0.005     
 10 210 344 1.638 34.40 26.5 288.262
Trend: 22.780        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/06/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 505 0.485 10.10 26.0 0.000
Test Chemical 1,2-Epoxy-3,3,3-trichloropropane 
 0.5       
 50 1048 508 0.485 10.16 26.0 0.018 
1.6       
 50 1039 565 0.544 11.30 26.0 12.204 
5         
 50 1044 569 0.545 11.38 26.0 12.457 
16         
 50 1048 1369 1.306 27.38 26.0 169.537 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1037 611 0.589 12.22 26.0 21.573
Cyclophosphamide 
 0.6       
 10 212 269 1.269 26.90 26.0 161.814
Trend: 21.280        
Probability: 0.000