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Study Information
Study Attribute Value
CEBS Accession Number: 002-01055-0004-0000-7
Chemical Name: 1,2-Epoxy-3,3,3-trichloropropane
CASRN: 3083-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 919832_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 05/14/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
5         
 200 14 0.070 6.0 3 0.015 1.5 11 0.055 5.0 0 0.000 0.0 
10         
 200 10 0.050 5.0 2 0.010 1.0 8 0.040 4.0 0 0.000 0.0 
16         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 49 0.245 20.5 23 0.115 10.5 26 0.130 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 33 0.660 46.0 19 0.380 26.0 14 0.280 26.0 0 0.000 0.0
Trend: -0.057 0.393 -0.382  
Probability: 0.523 0.347 0.649  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/14/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
10         
 200 9 0.045 4.0 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0 
16         
 200 15 0.075 7.0 9 0.045 4.5 6 0.030 3.0 0 0.000 0.0 
30         
 200 10 0.050 4.5 3 0.015 1.5 7 0.035 3.0 0 0.000 0.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 29 0.145 13.0 6 0.030 3.0 23 0.115 10.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 19 0.380 34.0 3 0.060 6.0 16 0.320 30.0 0 0.000 0.0
Trend: 2.032 1.351 1.397  
Probability: 0.021 0.088 0.081  


Trial #:2   Activation: No Activation    Date: 07/23/1986    Harvest Time: 17 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
5         
 200 12 0.060 5.0 2 0.010 1.0 10 0.050 4.5 0 0.000 0.0 
10         
 200 189 0.945 46.0 77 0.385 26.5 72 0.360 28.0 40 0.200 4.0 
16         
 200 163 0.815 30.5 54 0.270 16.5 59 0.295 19.0 50 0.250 5.0 
30         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 148 0.740 44.0 78 0.390 29.5 60 0.300 25.0 10 0.050 1.0
Mitomycin-C 
 0.125     
 50 73 1.460 66.0 37 0.740 50.0 26 0.520 40.0 10 0.200 1.0
Trend: 10.790 8.002 7.800  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/23/1986    Harvest Time: 18 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0
Test Chemical: 1,2-Epoxy-3,3,3-trichloropropane 
10         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
16         
 200 12 0.060 4.5 5 0.025 2.0 7 0.035 3.5 0 0.000 0.0 
30         
 200 317 1.585 61.5 150 0.750 45.5 167 0.835 42.0 0 0.000 0.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 67 0.335 25.5 21 0.105 8.5 46 0.230 19.0 0 0.000 0.0
Cyclophosphamide 
5         
 50 43 0.860 52.0 14 0.280 22.0 19 0.380 32.0 10 0.200 1.0
Trend: 15.214 13.727 11.915  
Probability: 0.000 0.000 0.000