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Study Information
Study Attribute Value
CEBS Accession Number: 002-01058-0001-0000-7
Chemical Name: 1,2-Epoxybutane
CASRN: 106-88-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333393_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/11/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 406 0.390 8.12 26.5 -2.123
Dimethyl Sulfoxide 
0         
 50 1045 416 0.398 8.32 26.5 0.000
Test Chemical 1,2-Epoxybutane 
1.6       
 50 1041 497 0.477 9.94 26.5 19.930 
5         
 50 1034 531 0.514 10.62 26.5 29.002 
16         
 50 1035 735 0.710 14.70 26.5 78.390 
50         
 50 1044 1572 1.506 31.44 26.5 278.247 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1043 470 0.451 9.40 26.5 13.197
Mitomycin-C 
 0.01      
 50 1046 2571 2.458 51.42 26.5 517.438
Trend: 29.448        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/14/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 367 0.354 7.34 26.0 -18.124
Dimethyl Sulfoxide 
0         
 50 1047 453 0.433 9.06 26.0 0.000
Test Chemical 1,2-Epoxybutane 
16         
 50 1030 636 0.617 12.72 26.0 42.715 
50         
 50 1037 1185 1.143 23.70 26.0 164.112 
100         
 50 1045 1739 1.664 34.78 26.0 284.620 
160         
 50 1033 2460 2.381 49.20 26.0 450.406
Positive Control Mitomycin-C 
 0.001     
 50 1040 1208 1.162 24.16 26.0 168.462
Mitomycin-C 
 0.01      
 25 509 1652 3.246 66.08 26.0 650.137
Trend: 43.938        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/23/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 451 0.431 9.02 26.0 -4.134
Dimethyl Sulfoxide 
0         
 50 1046 470 0.449 9.40 26.0 0.000
Test Chemical 1,2-Epoxybutane 
16         
 50 1030 501 0.486 10.02 26.0 8.252 
50         
 50 1043 632 0.606 12.64 26.0 34.855 
160         
 50 1045 1090 1.043 21.80 26.0 132.137 
500         
 50 1049 2151 2.051 43.02 26.0 356.351 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 790 0.755 15.80 26.0 68.085
Cyclophosphamide 
2         
 50 1050 2006 1.910 40.12 26.0 325.183
Trend: 39.882        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/14/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 461 0.443 9.22 26.0 0.000
Negative (Not Specified) 
0         
 50 1039 465 0.448 9.30 26.0 0.965
Test Chemical 1,2-Epoxybutane 
16         
 50 1046 466 0.446 9.32 26.0 0.505 
50         
 50 1045 564 0.540 11.28 26.0 21.757 
160         
 50 1043 775 0.743 15.50 26.0 67.629 
500         
 50 1042 1631 1.565 32.62 26.0 253.117
Positive Control Cyclophosphamide 
 0.3       
 50 1036 678 0.654 13.56 26.0 47.639
Cyclophosphamide 
2         
 10 207 430 2.077 43.00 26.0 368.630
Trend: 30.014        
Probability: 0.000